Effectiveness of the use of enrofloxacin of fast action in the treatment of neonatal diarrhea in Holstein calves / Eficácia do uso de Enrofloxacina de ação rápida no tratamento da diarreia neonatal em bezerros da raça Holandês
Montagner, Paula; Weschenfelder, Marina Menoncin; Pereira, Rubens Alves; Maffi, Andressa Stein; Moraes, Fabiane Pereira de; Brauner, Cássio Cassal; Rabassa, Viviane Rõhrig; Del Pino, Francisco Augusto Burkert; Xavier, Eduardo Gularte; Corrêa, Marcio Nunes.
Acta sci. vet. (Online);
42: Pub. 1218, Oct. 31, 2014. tab, graf
Artigo
em Português
| VETINDEX
| ID: vti-30942
Resumo
Background: Diarrhea generates economic impacts due high morbidity and mortality losses, and results in delayed physical development and treatment costs. The therapy consists in using broad-spectrum antibiotics, such as drugs belongingto the quinolones group, as the enrofloxacin. It is currently available on the market a single dose enrofloxacin, whichreaches plasma peak concentration five hours after the injection, and in 30 minutes reaches the therapeutic concentrationsin plasma. The aim of this study was to evaluate the clinical, haematological and biochemical parameters in calves withdiarrhea treated with a single dose of a fast action response enrofloxacin.Materials, Methods & Results: For this study, 10 heifers with 1 day of life were classified according appearance of diarrhea clinical symptoms in two experimental groups: Sickness Group (SG) n = 5 and Healthy Group (HG) n = 5. For theSG, the adopted therapeutic protocol was a single dose (7.5 mg / kg / IM) of a fast action enrofloxacin and the GS animalswere not treated. During the first five weeks of life, the animals were clinically monitored (heart rate, respiratory rate, rectaltemperature and capillary refill time) and blood samples were collected for hemogram and biochemical analysis of albumin(ALB), total protein (TP) and globulin (GLO), and determination of the relations ALB:GLO and TP:fibrinogen. Besides,the growth measures were used to obtain the average daily gain (ADG) of weight, height, chest girth and rump width.From the diagnosis of diarrhea, the animals were monitored daily for 3 consecutive days by clinical examination and bloodcollection for hemogram. The statistical analyzes were performed by using version 9.0 SAS software. The ADG of weight,height, chest girth, rump width and concentrations of blood metabolites (ALB, TP, GLO, ALB:GLO, TP:Fibrinogen) didnot differ between the groups during the first five weeks of life. Frequencies of heart rate (HR)...(AU)
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