Analgesic and sedative evaluation of two protocols in swine underwent orchiectomy / Avaliação analgésica e sedativa de dois protocolos em suínos submetidos à orquiectomia

ABSTRACT

Introduction: Sedation and analgesia are essential in chemical restraint in pigs for various procedures. Analgesia allows theanimal to be free of the deleterious effects of pain, which are related to stress and weight loss. In this sense, the aim of this studywas evaluate two sedation protocols in pigs undergoing elective orchiectomy.Materials, Methods and Results: There were used 22 pigs with three months old, with an average weight of 19.05 ± 2.46 kg.The food was withheld for 12 h and water for 6 h. After fasting period, they were mask-induced with isofl urane, for surgicalpreparation and than they were recovered from anesthesia. After 30 min, the animals were allocated in two groups ketamine/midazolam /Tramadol (CMT, n = 11) who received 5 mg kg-1 of ketamine, 1 mg kg,-1 of midazolam and 4 mg kg-1 of tramadol,and azaperone/tramadol (AT, n = 11) which received 6 mg kg-1 of azaperone and 4 mg kg-1 of tramadol, both treatments administered intramuscularly. The parameters evaluated were heart rate (HR) through the stethoscope, respiratory frequency (f) by themovement of the rib cage, systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP) trougha catheter in femoral artery, rectal temperature (RT) with a digital thermometer, arterial blood gas analysis, with an blood gasanalyzer, and blood count and biochemical profi le. The moments of evaluation were baseline, and 10, 20, 30 and 40 min aftertreatments, corresponding to M0, M1, M2, M3 and M4, respectively. Score of sedation, muscle relaxation, response to stimuli,time to sternal recumbency, time to deambulation, time to full recovery and quality of recovery were also evaluated. The meansbetween groups in the same time were analyzed by Students t test and the means between times, in the same group by analysisof variance followed by Student Newmann Keuls test (P  0.05). Non parametrical data were analyzed with Mann Whitney rank...(AU)