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Minimum dose of levothyroxine restored the autonomic balance on a Dalmatian female dog with primary hypothyroidism
Costa, Paula Priscila Correia; Waller, Stefanie Bressan; Rocha, Michaela Marques; Rocha, Danilo Galvão; Alves, Caroline Castagnara; Soares, Matheus de Azevedo; Silva, Eduardo Gonçalves da; Vasconcellos, Amanda Leal de.
Afiliação
  • Costa, Paula Priscila Correia; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Waller, Stefanie Bressan; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Rocha, Michaela Marques; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Rocha, Danilo Galvão; Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza. BR
  • Alves, Caroline Castagnara; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Soares, Matheus de Azevedo; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Silva, Eduardo Gonçalves da; Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Clínica Veterinária. Pelotas. BR
  • Vasconcellos, Amanda Leal de; Universidade Estadual do Ceará. Departamento de Medicina Veterinária. Fortaleza. BR
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.572-4 jan. 2020. ilus, tab
Article em En | VETINDEX | ID: biblio-1458399
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Background:

Hypothyroidism is an endocrine disease that leads to a reduction in the hormones thyroxine (T3) and triiodothyronine (T4), which therapy with levothyroxine restores the clinical signs related to the metabolic rate. Due to the influence of thyroid hormones on the heart, which is under the constant influence of the autonomic nervous system (ANS), dogs with hypothyroidism can develop bradycardia, arrhythmia, and dysautonomia. Heart rate variability (HRV) assesses autonomic modulation by the Holter method, which is scarce in dogs. We aimed to report the cardiac and autonomic effects of the primary hypothyroidism untreated and treated with levothyroxine in a canine case by Holter monitoring. Case A 7-year-old female Dalmatian, weighing 36 kg, was referred for clinical evaluation due to apathy, weight gain, low hair quality, and lethargy. On physical examination, alopecic lesions on the hind limbs and tail, as well as bradycardia with a heart rate (HR) of 40-50 beats per minute (bpm) were observed, in addition to a 3/6 mitral murmur and 2/6 tricuspid murmur. Given the suspicion of thyroid gland disorder, the blood hormonal measurement revealed an increase in thyroidstimulating hormone (TSH; 0.65 ng/mL) and a decrease in free T4 (0.11 ng/mL) and total T4 (0.44 ng/mL), confirming primary hypothyroidism. Therapy was started with a minimum dose of levothyroxine (0.913 mg, every 12 h), which clinical signs were restored in 5 months of treatment, with weight loss, hair growth, and active behavior. To assess the impact of untreated and treated hypothyroidism on the patient’s ANS, a Holter monitoring exam was performed for 24 h before and after therapy. Before treatment, the average HR was 75 bpm, and the HR2.0s), 1st-degree atrioventricular blocks (AVB), six...
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta sci. vet. (Impr.) / Acta sci. vet. (Online) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta sci. vet. (Impr.) / Acta sci. vet. (Online) Ano de publicação: 2020 Tipo de documento: Article