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Diabetes insipidus central em felino jovem / Central diabetes insipidus in a young feline

Strack, Adriane; Moretto, Luana; Di Concilio, Carla; Pereira, Marcy Lancia.
Acta sci. vet. (Online); 48(suppl.1): Pub. 527, 28 ago. 2020. ilus, graf
Artigo em Português | VETINDEX | ID: vti-31884


Background: Central diabetes insipidus (CDI) is an endocrine disorder caused by the failure to produce, transport, orrelease ADH. This disease may show a primary etiology (idiopathic or congenital) or a secondary one (trauma or neoplasms). It is characterized by signs such as polyuria and polydipsia. The definitive diagnosis is obtained by the two-stepwater deprivation test; the absence of adequate urinary concentration in the first stage confirms the diagnosis of diabetesinsipidus and, in the second stage, the response to the application of synthetic desmopressin confirms a central origin.Because CDI is rare in felines, the aim of this study was to report the occurrence of a case of CDI, probably of congenitalprimary origin, in an 8-month-old kitten.Case: An 8-month-old male feline, castrated, 3.2 kg, was brought to consultation with a report of polydipsia, polyuria,smaller size and weight, and lower activity when compared to his brother, for several months. On physical examination,lethargy, body score 2/5, and mild dehydration were noted, as well as deciduous teeth that should have already been replaced. Abdominal ultrasound and laboratory tests were requested, which ruled out chronic kidney disease (CKD), diabetesmellitus (DM), hyperadrenocorticism (HAC), and hyperthyroidism. Due to the fact that urinalysis evidenced hyposthenuria(urinary density [UD] 1.004), CDI was suspected. The patient underwent a water deprivation test and, after 7.5 h, lost4.7% of his initial weight, while UD was 1.012, confirming the diagnosis of DI. The investigation then proceeded to theevaluation of the response to synthetic desmopressin by the application of 5 U IM. Two h later, UD was 1.019, confirming...(AU)
Biblioteca responsável: BR68.1
Localização: BR68.1