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Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?
Gremski, Luiza Helena; Matsubara, Fernando Hitomi; Justa, Hanna Câmara da; Schemczssen-Graeff, Zelinda; Baldissera, Antonielle Beatriz; Schluga, Pedro Henrique de Caires; Leite, Isabel de Oliveira; Boia-Ferreira, Marianna; Wille, Ana Carolina Martins; Senff-Ribeiro, Andrea; Veiga, Silvio Sanches.
Afiliação
  • Gremski, Luiza Helena; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Matsubara, Fernando Hitomi; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Justa, Hanna Câmara da; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Schemczssen-Graeff, Zelinda; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Baldissera, Antonielle Beatriz; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Schluga, Pedro Henrique de Caires; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Leite, Isabel de Oliveira; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Boia-Ferreira, Marianna; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Wille, Ana Carolina Martins; State University of Ponta Grossa. Department of Molecular Structural Biology and Genetics. Ponta Grossa. Brasil
  • Senff-Ribeiro, Andrea; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
  • Veiga, Silvio Sanches; Federal University of Paraná. Department of Cell Biology. Curitiba. Brasil
J. Venom. Anim. Toxins incl. Trop. Dis. ; 27: e20200188, 2021. tab, graf
Article em En | VETINDEX | ID: vti-31959
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition that often includes a threatening necrotic skin lesion near the bite site along with a remarkable inflammatory response. Systemic disorders such as hemolysis, thrombocytopenia, and acute renal failure may occur, but are much less frequent than the local damage. It is already known that phospholipases D, highly expressed toxins in Loxosceles venom, can induce most of these injuries. However, this spider venom has a great range of toxins that probably act synergistically to enhance toxicity. The other protein classes remain poorly explored due to the difficulty in obtaining sufficient amounts of them for a thorough investigation. They include astacins (metalloproteases), serine proteases, knottins, translationally controlled tumor proteins (TCTP), hyaluronidases, allergens and serpins. It has already been shown that some of them, according to their characteristics, may participate to some extent in the development of loxoscelism. In addition, all of these toxins present potential application in several areas. The present review article summarizes information regarding some functional aspects of the protein classes listed above, discusses the directions that could be taken to materialize a comprehensive investigation on each of these toxins as well as highlights the importance of exploring the full venom repertoire.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. Ano de publicação: 2021 Tipo de documento: Article