Concentração sérica da proteína C reativa (PCR) em cadelas portadoras de neoplasias mamárias / Serum concentration of C-reactive protein (CRP) in bitches whit mammary gland tumor

ABSTRACT

There is strong evidence that inflammation plays a key role in all stages of tumorigenesis. In human medicine, C-reactive protein (CRP) is frequently used in tests for neoplastic biomarkers, however, few studies are available on the serum concentration of CRP in cases of canine mammary tumors (CMT). The aim of this study was to evaluate the serum concentrations of CRP in bitches with CMT and its association with prognostic factors. Thirty bitches participated in the work, which were equally divided into two groups, with and without CMT. Bitches with CMT have higher concentrations of CRP (4.0±1.9mg/L) compared to the control group (1.0±1.2mg/L) and their values were positively correlated with inflammation and/or macroscopic ulceration (r=0.4), tumor size (r=0.6), histopathological grade (r=0.6), metastatic lymph node (r=0.6) and clinical stage (r=0.8).