Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study
Freitas, Jose Octavio Gonçalves de; Quieregatto, Paulo Rogério; Hochman, Bernardo; Lapin, Guilherme Abbud Franco; Mella, Stella Maria Botequio; Maximino, Jessica Ruivo; Chadi, Gerson; Ferreira, Lydia Masako.
Acta cir. bras.;
30(8): 523-528, Aug. 2015. ilus
Artigo
em Inglês
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| ID: vti-334075
Resumo
To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats. Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting. No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups. The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.(AU)
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