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Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Ribeiro, Sofia Miranda de Figueiredo; Moya, Amanda Maria Tomazini Munhoz; Braga, Camila Bitu Moreno; Domenici, Fernanda Aparecida; Feitosa, Marley Ribeiro; Feres, Omar; Rocha, José Joaquim Ribeiro da; Cunha, Selma Freire de Carvalho da.
Acta cir. bras.; 31(supl.1): 24-28, 2016. tab
Artigo em Inglês | VETINDEX | ID: vti-341437

Resumo

PURPOSE : This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. RESULTS: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin[70.1 ng/mL (CI95% 55.8-84.5) vs.53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations [120 µg/dL(CI95% 114-126) vs. 106 µg/dL(CI95% 98-114), p 0.01] and the Cu/Zn ratio [1.59 (CI95% 1.48-1.71)vs. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. CONCLUSION: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.(AU)
Biblioteca responsável: BR68.1
Localização: BR68.1