Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
A. Ismaiel, Ahmed; A. El-Sayed, El-Sayed; A. Mahmoud, Asmaa.
Braz. J. Microbiol.;
41(4)2010.
Artigo
em Inglês
| VETINDEX
| ID: vti-444615
Resumo
A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.
Biblioteca responsável:
BR68.1
Texto completo