Histopathological and immunohistochemical characterization of pneumonia caused by co-infection between Pasteurella multocida and Mycoplasma hyopneumoniae in swine / Caracterização histopatológica e imuno-histoquímica da pneumonia causada pela co-infecção por Pasteurella multocida e Mycoplasma hyopneumoniae em suínos
Ludwig Takeuti, Karine; Terumi Negrão Watanabe, Tatiane; Amaral de Castro, Luiza; Driemeier, David; Emilio Santos Neves de Barcellos, David.
Acta sci. vet. (Online);
41: 01-06, 2013.
Artigo
em Português
| VETINDEX
| ID: vti-480152
Resumo
Background: The infection with Mycoplasma (M.) hyopneumoniae is a major cause of pneumonia in pigs worldwide, but the interaction between M. hyopneumoniae and Pasteurella (P.) multocida has been described with low frequency and histopathological characteristics of this association have not been described. In Brazil this interaction is considered very important and is found in most cases of pigs with pneumonia and pleuritis at slaughter. The objective of this work was to examine 41 samples of swine lungs collected at slaughter, from which P. multocida had been isolated and to study the co-infection with M. hyopneumoniae by histopathology and immunohistochemistry (IHC). Materials, Methods & Results: Among lung tissue samples obtained from necropsy in swine with clinical signs of pneumonia, 41 that had shown positive results on bacteriological examination for P. multocida were selected. The histopathological findings of bronchopneumonia were classified in different degrees according to the extension of the lesion as follow: absent (0), mild (+), moderate (+ +) and severe (+ + +). Hyperplasia of bronchial and bronchiolar epithelium was classified as absent (0) and present (+). The bronchus associated lymphoid tissue (BALT) hyperplasia lesions were classified as absent (0), (+) when the peribronchial and peribronchiolar lymphocytic infiltrate were discrete, (+ +) when the peribrPasteurella (P.) multocida causa a pasteurelose pulmonar dos suínos, sendo necessária a interação com outros agentes para causar pneumonia. Entretanto, existem evidências de que possa atuar como patógeno primário, pois em suínos SPF (Specific Pathogen Free) inoculados experimentalmente, um determinado isolado da bactéria foi capaz de causar lesões de pleurite e pericardite. Mycoplasma (M.) hyopneumoniae, agente da pneumonia enzoótica suína, é um patógeno primário que predispõe a infecções secundárias, principalmente com P. multocida. A relação entre os dois agentes é explicada pelo efeito imunodepressor exercido pelo Mycoplasma devido à necrose do epitélio do trato respiratório e ciliostase, além da modulação do sistema imune. [...]
Biblioteca responsável:
BR68.1
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