Your browser doesn't support javascript.

Portal de Pesquisa da BVS Veterinária

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
Imprimir Exportar

Formato de exportação:

Exportar

Exportar:

Email
Adicionar mais destinatários

Enviar resultado
| |

Efeito do diidrocloreto de 2, 2-azobis (2-metilpropionamidina) sobre músculo liso de traquéia de rato / The effects of 2, 2-azobis (2-amidinopropane) dihydrochloride on tracheal smooth muscle

Gomes, Maria Diana Moreira; Neves, Dieniffer Peixoto; Rodrigues, Karilane Maria Silvino; Teixeira, Ana Carolina Cardoso; Lima, Felipe Crescêncio; Cardoso José Henrique, Leal.
Ciênc. Anim. (Impr.); 25(3): 31-40, 2015. tab, graf
Artigo em Português | VETINDEX | ID: vti-481232

Resumo

The effects of 2,2′-Azobis(2-methylpropionamidine) dihydrochloride (AAPH), an inducer agent of free radicals (peroxyl radical) formation, on the rat tracheal smooth muscle. The experiments were performed on tracheal ring preparations maintained in aerated modified Tyrode solution, in pH 7,4 at 37 °C. The force developed by the tracheal smooth muscle was measured by the isometric force transducer connected to a computerized system. On contractions induced by acetylcholine (10 M), AAPH presented a biphasic effect: contraction potentiation at low concentration on intact and denuded epithelium preparations (CE50 = 0,8776  0,415 mM and CE50 = 0,3338  0,343 mM, respectively); and contraction inhibition at high concentration on intact and denuded epithelium preparations (CE50 = 81,55 62 4,284 mM and CE50 = 57,7786  8,607 mM, respectively). On electromechanic coupling, AAPH inhibited contractions induced by KCl (60 mM) on intact and denuded epithelium preparations (CE50 = 57,4037  4,652 mM and CE50 = 32,9650  2,652 mM, respectively). In conclusion, AAPH presented a concentration-dependent biphasic effect (pontentiation and inhibition) on pharmacomechanic coupling while it was able to only inhibit the electromechanic coupling. In conclusion, AAPH presented a concentration-dependent biphasic effect (pontentiation and inhibition) on pharmacomechanic coupling while it was able to only inhibit the electromechanic coupling. Comparing the present data with those available in literature for H2O2, we can suggest that these observed effects are not specific for AAPH, but they are derived from the free radicals induced by AAPH.(AU)
Biblioteca responsável: BR68.1
Localização: BR68.1