Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki.

Afiliação

Park, Soon-Nang; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. Republic of Korea
Ahn, Sug-Joon; Chosun University. School of Dentistry. Dental Research Institute. Gwangju. Republic of Korea
Kook, Joong-Ki; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. Republic of Korea

Braz. J. Microbiol. ; 46(2): 613-617, Apr.-Jun. 2015. tab, graf

Article em En | VETINDEX | ID: vti-481389

Biblioteca responsável: BR1.1

Localização: BR68.1

ABSTRACT

ABSTRACT

In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.(AU)

Assuntos

Antibacterianos/farmacologia; Vias Biossintéticas; Vias Biossintéticas/genética; Ácido Oleanólico/farmacologia; Peptidoglicano/biossíntese; Streptococcus mutans; Triterpenos/farmacologia; Regulação Bacteriana da Expressão Gênica

Palavras-chave

Ursolic acid; Oleanolic acid; Peptidoglycan biosynthesis; Streptococcus mutans UA159

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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2015 Tipo de documento: Article / Project document

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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2015 Tipo de documento: Article / Project document