Immune response and neutralization capacity of antibodies produced in young sheep immunized with Crotalus durissus terrificus native or Cobalt-60 irradiated venom / Resposta imune e capacidade de neutralização de anticorpos produzidos em ovinos jovens imunizados com veneno de Crotalus durissus terrificus nativo e irradiado com Cobalto 60
Ferrreira Junior, Rui Seabra; Nascimento, Nanci do; Couto, Renata; Alves, Janaína Baptista; Meira, Domingos Alves; Barraviera, Benedito.
Braz. j. vet. res. anim. sci;
46(3): 207-214, 2009. graf, tab, ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-5069
Resumo
The ELISA technique was used to evaluate and compare young ovine humoral immune response during crotalic antiserum production. Animals were clinically evaluated throughout this process, and the neutralizing capacity of antisera raised against natural (NV) and Cobalt-60 irradiated (IrV) venoms of Crotalus durissus terrificus (C.d.t.) was verified by means of in vitro challenges. Three groups of six animals each were used: G1 received NV; G2 was inoculated with IrV; and G3 was used as control. Animals received six immunizations during 84 days at 14-day intervals. ELISA of antibody profile showed significant difference (p<5%) between experimental groups (G1
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