Expressão imunoistoquímica da proteína S-100 na discondroplasia da tíbia / S-100 protein immunostaining in tibial dyschondroplasia
Capela e Silva, F; Lamy, E; Reis, J. C; Potes, J. C; Pereira, A; Cabrita, A. S.
Arq. bras. med. vet. zootec;
62(2): 495-498, abr. 2010. ilus, tab
Artigo
em Português
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| ID: vti-5777
Resumo
It was compared, by immunohistochemistry, the expression of S-100 protein from normal and tibial dyschondroplasia (TD) growth plates. The results suggest that S-100 may be involved in growth plate homeostasis. The expression of S-100 in dyschondroplastic chondrocytes may be due to a low level of calcium in the lesion and/or compression of chondrocytes by the accumulated matrix. One further possibility is the association between S-100 and the regulation of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs). Further studies will be necessary to provide insight into involvement of S-100 in tibial dyschondroplasia development and the precise nature of the pathology.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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