Expressão imunoistoquímica da proteína S-100 na discondroplasia da tíbia / S-100 protein immunostaining in tibial dyschondroplasia

ABSTRACT

It was compared, by immunohistochemistry, the expression of S-100 protein from normal and tibial dyschondroplasia (TD) growth plates. The results suggest that S-100 may be involved in growth plate homeostasis. The expression of S-100 in dyschondroplastic chondrocytes may be due to a low level of calcium in the lesion and/or compression of chondrocytes by the accumulated matrix. One further possibility is the association between S-100 and the regulation of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs). Further studies will be necessary to provide insight into involvement of S-100 in tibial dyschondroplasia development and the precise nature of the pathology.(AU)