Clinicopathological studies on spontaneous Hymenolepis diminuta infection in wild and laboratory rats

ABSTRACT

Out of 78 adult laboratory and wild rats investigated for parasitic diseases, 19.23% were diagnosed positive for spontaneous Hymenolepis diminuta infection. Infection was more in laboratory rats (24%) than wild rats (10.71%). Sex wise distribution of H. diminuta infection was also higher male laboratory rats than females while wild rat females were found free from this tapeworm. Value of hemoglobin was significantly decreased in H. diminuta infected laboratory rats than controls. Significant increased plasma protein values in H. diminuta infected wild rats than uninfected wild rats were observed. Serum values of alkaline phosphatase, SGPT and SGOT were significantly increased in H. diminuta infected wild rats than uninfected wild rats and other groups. Tissue enzyme studies revealed that although there were alterations of different enzymes in non-target organs of H. diminuta infected rats, but only lipid peroxidation, acetylcholinesterase and catalase were altered in target organ intestine. On SEM, the segments of H. diminuta showed width from 1120 to 1160 µm while length ranged from 120 to 150 µm. Most of segments had vertical lining and raised border on its each side of circumference. On necropsy examination, intestines were found to contain 25-40 mm long and about 1 mm wide, 3-4 or more tapeworms in each rat. Relative weight of intestine was significantly increased in H. dim