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Histopathological and immunophenotypical analysis of canine mucinous rectal adenocarcinoma

Araújo Damasceno, Karine; Salgado Rabelo, Bruna; de Oliveira Gamba, Conrado; Maria de Souza, Cristina; Cunha Campos, Liliane; Bonolo de Campos, Cecília; Ferreira, Enio; Dantas Cassali, Geovanni.
Braz. J. Vet. Pathol.; 5(2): 74-77, 2012.
Artigo em Inglês | VETINDEX-Express | ID: vti-689787

Resumo

Rectal adenocarcinomas are uncommon in dogs and usually present poor prognosis. The present work describes the morphological and immunophenotypical findings of a rectal mucinous adenocarcinoma in a bitch. Histological analysis revealed a malignant epithelial proliferation in a tubulopapillary pattern forming multiple intratubular cell layers. Moderate amount of PAS-positive amorphous eosinophilic content within neoplastic tubules and extruded into the stroma was observed. Immunohistochemical analysis revealed neoplastic cells considered positive for cytokeratin, Her-2, COX-2 and E-caderin and with low p53 expression. A high proliferation index was observed. Based on histological and immunophenotypical findings, the diagnosis of mucinous adenocarcinoma was established.
Biblioteca responsável: BR68.1