Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator
Nunes, Vinicius Rodrigues Taranto; Vidigal, Paula Vieira Teixeira; Pereira, Márcio Tadeu; Ladeira, Luís Carlos Duarte; Barbuto, Rafael Calvão; Duval-Araujo, Ivana.
Acta cir. bras.;
32(4): 319-324, Apr. 2017. ilus
Artigo
em Inglês
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| ID: vti-694955
Resumo
Purpose: To describe a new model of actinic enteritis that does not use radiotherapy machines. Methods: Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (group C) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. Results: In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon. Conclusion: We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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