Electrocardiographic study in dogs given amitraz intravenously / Estudo eletrocardiográfico em cães submetidos à aplicação intravenosa de amitraz

ABSTRACT

Amitraz is a widely used alpha-two agonist insecticide and acaricide formamidine that is very effective to control ectoparasites. This drug can promote dose-dependent changes in cardiovascular parameters, such as bradycardia, first and second-degree atrioventricular block, decreased cardiac output, hypertension, and hypotension. Therefore, the aimof this research was to evaluate the possible electrocardiographic changes in dogs receiving an intravenous injection of amitraz. Eleven healthy mongrel mature dogs of either sex were used. They were given amitraz 1mg.kg-1 by intravenous route. Electrocardiography was recorded immediately before (baseline level) and then at 1, 5, 10, 20, 30, 40, 50, and 60 minutes after the drug administration. A paired t test was used to analyze data at a significance level of 5% (p