Effects of Aldrin acute administration on open field behavior and seizure of rats / Alterações na atividade geral observada em campo aberto e convulsões induzidas pela administração aguda de um praguicida organoclorado (Aldrin) em ratos
Martho Bernardi, Morio; Palermo Neto, João; de Souza Apinoso, Helenice.
Braz. j. vet. res. anim. sci;
26(1): 69-74, 1989.
Artigo
em Português
| VETINDEX
| ID: vti-726935
Resumo
The acute symptoms of organochIoride intoxication in rats were observed and described in details. In addition, it was study the effects of subconvuIsivant doses of Aldrin (10, 20 or 30 mg/kg) on general activity of rats observed in an open-field. Thus, the following symptoms were observed after acute Aldrin in toxications: motor incoordination, decreased activity, muscular shakes, contractions of the muscles of the abdominal region, salivation and compulsive gnawing, postural immobility with "fixed eye and tonicclonic convulsions followed or not by rats death. The convulsant and lethal doses of Aldrin were, respectively, 52.0 mg/kg (47.3 - 57.2) and 60.5 mg/kg (46.2 - 79.3). It was possible also observed that both locomotion and rearing frequencies of rats treated with subconvulsivant Aldrin doses decreased in relation of the control animals; contrary, immobility duration was higher in the experimental animals treated with Aldrin. It was suggested that reduction in general activity was related to a decreased brain catecholamines levels induced by the pesticide.O presente trabalho descreve, em sequência, os sintomas da intoxicação aguda por um praguicida organoclorado ldrin) e estuda os efeitos da administração de doses subconvulsivantes de Aldrin na atividade geral de ratos observados em campo aberto. Os resultados mostraram que as doses convulsivantes 50% e letal 50% foram de 52,0 mg/kg (47,3 - 57,2) e de 60,5 mg/kg (46,2 - 79,3), respectivamente. A administração das doses subconvulsivantes de Aldrin diminuiu não só as frequências de locomoção e levantar, bem como aumentou a duração de parado. Sugeriu-se que a redução da atividade geral representa um efeito pré-convulsivo do Aldrin relacionado, provavelmente, como decréscimo dos níveis de catecolaminas cerebrais.
Biblioteca responsável:
BR68.1
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