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Denaturation of actomiosine from rabbit striated muscle by promethazine / Desnaturação da actomiosina de músculo estriado de coelho pela prometazina

Medina, Heitor; Varela de Carvalho, Fernando; Emily Cury, Arlete; Bacila, Metry.
Artigo em Português | VETINDEX | ID: vti-727749

Resumo

Interaction between Promethazine and contractile proteins prepared from rabbit striated muscle has been studied by methods based on the fact that the phenothiazinic compound acting upon actiomiosine causes a physical change in the protein, which results in the loss of the capability of changing from the F to the G forms. Measurements have been carried out on the effect of Promethazine to cause turbidity when added to a solution of actomiosine G. Furthermore, it has been shown that actiomiosine F is able to remove Promethazine from a solution to which both actomiosine F and Promethazine have been added in suitable preparations. When a solution of actiomiosine G is dropped over the surface of a column of distilled water, it changes to the F form showing a well round shapped and limited drop. However, when actomiosine G is previously treated with Promethazine in suitable concentrations, and it is dropped over the surface of a column of water, the drop of actomiosin F becomes shapeless by loosing its physical form. A method, called the drop method has been devised in order to quantitate this phenomenon due to the fact that such physical changes in the properties of actomiosine F are related to two parameters: the concentration of Promethazine and the height from which the dropping is carried out on the water surface.
O artigo apresenta resumo em inglês.
Biblioteca responsável: BR68.1