Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury
Ribeiro Júnior, Rubens Fernando Gonçalves; Couteiro, Rodrigo Paracampo; Monteiro, Andrew Moraes; Rodrigues, Ivone Aline da Silva; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Galvão, Lucas Nascimento; Lopes, Luiz Renato Oliveira; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques.
Acta cir. bras.;
32(11): 949-955, nov. 2017. graf, tab
Artigo
em Inglês
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| ID: vti-728464
Resumo
Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. Results: Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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