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Óleos essenciais e seus compostos bioativos no controle de nematoides gastrintestinais de pequenos ruminantes / Essential oils and their bioactive compounds in the control of gastrointestinal nematodes of small ruminants

André, Weibson Paz Pinheiro; Ribeiro, Wesley Lyeverton Correia; Oliveira, Lorena Mayana Beserra de; Macedo, Iara Tersia Freitas; Rondon, Fernanda Cristina Macedo; Bevilaqua, Claudia Maria Leal.
Acta sci. vet. (Online); 46: 1-14, 2018. tab
Artigo em Português | VETINDEX | ID: vti-728662

Resumo

Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics and anthelmintic activity of EO, their isolated compounds and drug delivery systems in the control of GIN.Review: Essential oils are a complex blend of bioactive compounds with volatile, lipophilic, usually odoriferous and liquid substances. EO are composed of terpenes, terpenoids, aromatic and aliphatic constituents. EO has various pharmacological activities of interest in preventive veterinary medicine such as antibacterials, antifungals, anticoccicids, insecticides and anthelmintics. In vitro and in vivo tests are used to validate the anthelmintic activity of EO on GIN. In vitro tests are low cost screening tests that allow the evaluation of the anthelmintic activity of a large amount of bioactive compounds on eggs, first (L1) and third stage larvae (L3), and adult nematodes. The antiparasitic effect of EO is related to its main compound or to the interaction of the compounds. These bioactive compounds penetrate the cuticle of the nematodes by transcuticular diffusion, altering the mechanisms of locomotion, besides causing cuticular lesions. Following in vitro evaluation, the acute and sub-chronic toxicity test should be performed to assess the toxicity of the bioactive compounds and to define the dose to be used in in vivo tests.[...](AU)
Biblioteca responsável: BR68.1
Localização: BR68.1