Effect of melatonin on antioxidant capacity, inflammation and apoptotic cell death in lung tissue of diabetic rats
Onk, Didem; Onk, Oruç Alper; Erol, Hüseyin Serkan; Õzkaraca, Mustafa; Çomakli, Selim; Ayazoğlu, Tülin Akarsu; Kuyrukluyildiz, Ufuk; Ünver, Süheyla.
Acta cir. bras.;
33(4): 375-385, abr. 2018. ilus, tab, graf
Artigo
em Inglês
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| ID: vti-734641
Resumo
Purpose: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control group) was made up of healthy rats. Group 2 (diabetes group) received streptozotocin at a dose of 50 mg/kg/day for 5 days.Group 3 (diabetes plus melatonin group) received streptozotocin at a dose of 50 mg/kg/day for 5 days and then they received melatonin at a dose of 20 mg/kg/day between 28th and 35th days of the study. Results: Tissue MDA and MPO levels were found to be significantly higher in diabetes group compared to control group (p< 0.05) whilst administration of melatonin was found to significantly lower this increase down to normal levels (p <0.05). Bronchus associated lymphoid tissue (BALT) was more severe in diabetics whereas administration of melatonin alleviated this hyperplasia. Cleaved caspase 3 activity was severe in hyperplastic BALT in diabetic rats however in lowered down to moderate level when melatonin was administered. Conclusion: The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3.(AU)
Biblioteca responsável:
BR68.1
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