Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome
Acta cir. bras.
; 33(6): 483-490, jun. 2018. graf, tab
Article
em En
| VETINDEX
| ID: vti-734730
Biblioteca responsável:
BR68.1
ABSTRACT
Purpose:
To evaluate the effects of hypothermia treatment on meconium-induced inflammation.Methods:
Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed.Results:
The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively).Conclusion:
Meconium-induced inflammatory cytokine production is affected by the body temperature control.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2018
Tipo de documento:
Article