Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex
Acta cir. bras.
; 33(6): 472-482, jun. 2018. tab, graf
Article
em En
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| ID: vti-734731
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BR68.1
ABSTRACT
Purpose:
To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.Methods:
Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, the animals were submitted to a CSD electrophysiological recording and to brain oxidative stress evaluation.Results:
Our results showed that aging decreased CSD propagation velocity, catalase activity and glutathione/oxidized glutathione ratio (GSH/GSSG) in the brain cortex of the rats, and increased malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activity. The highest dose (300 mg/kg/day) of murici extract accelerated CSD, whereas the lowest (150mg/kg/day) decelerated, in both adult and aged animals. In contrast, aged animals supplemented with murici extract in both doses presented low MDA levels and high GSG/GSSG ratio in comparison to the control-aged animals.Conclusion:
Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.(AU)Palavras-chave
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VETINDEX
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En
Revista:
Acta cir. bras.
Ano de publicação:
2018
Tipo de documento:
Article
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