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A decade of experience with genetically tailored pig models for diabetes and metabolic research
Zettler, Silja; Renner, Simone; Kemter, Elisabeth; Hinrichs, Arne; Klymiuk, Nikolai; Backman, Mattias; Riedel, Evamaria Olga; Mueller, Christiane; Streckel, Elisabeth; Braun-Reichhart, Christina; Martins, Ana Sofia; Kurome, Mayuko; Keßler, Barbara; Zakhartchenko, Valeri; Flenkenthaler, Florian; Arnold, Georg Josef; Fröhlich, Thomas; Blum, Helmut; Blutke, Andreas; Wanke, Rüdiger; Wolf, Eckhard.
Afiliação
  • Zettler, Silja; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Renner, Simone; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Kemter, Elisabeth; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Hinrichs, Arne; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Klymiuk, Nikolai; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Backman, Mattias; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Riedel, Evamaria Olga; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Mueller, Christiane; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Streckel, Elisabeth; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Braun-Reichhart, Christina; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Martins, Ana Sofia; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Kurome, Mayuko; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Keßler, Barbara; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Zakhartchenko, Valeri; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
  • Flenkenthaler, Florian; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Arnold, Georg Josef; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Fröhlich, Thomas; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Blum, Helmut; Gene Center. Laboratory for Functional Genome Analysis. Munich. DE
  • Blutke, Andreas; German Research Center for Environmental Health. Neuherberg. DE
  • Wanke, Rüdiger; LMU Munich. Center for Clinical Veterinary Medicine. Institute of Veterinary Pathology. Munich. DE
  • Wolf, Eckhard; Center for Innovative Medical Models Department of Veterinary Sciences. Molecular Animal Breeding and Biotechnology. Munich. DE
Anim. Reprod. (Online) ; 17(3): [e20200064], 2020. graf, ilus
Article em En | VETINDEX | ID: biblio-1461531
Biblioteca responsável: BR68.1
ABSTRACT
Abstract The global prevalence of diabetes mellitus and other metabolic diseases is rapidly increasing. Animal models play pivotal roles in unravelling disease mechanisms and developing and testing therapeutic strategies. Rodents are the most widely used animal models but may have limitations in their resemblance to human disease mechanisms and phenotypes. Findings in rodent models are consequently often difficult to extrapolate to human clinical trials. To overcome this translational gap, we and other groups are developing porcine disease models. Pigs share many anatomical and physiological traits with humans and thus hold great promise as translational animal models. Importantly, the toolbox for genetic engineering of pigs is rapidly expanding. Human disease mechanisms and targets can therefore be reproduced in pigs on a molecular level, resulting in precise and predictive porcine (PPP) models. In this short review, we summarize our work on the development of genetically (pre)diabetic pig models and how they have been used to study disease mechanisms and test therapeutic strategies. This includes the generation of reporter pigs for studying beta-cell maturation and physiology. Furthermore, genetically engineered pigs are promising donors of pancreatic islets for xenotransplantation. In summary, genetically tailored pig models have become an important link in the chain of translational diabetes and metabolic research.
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Anim. Reprod. / Anim. Reprod. (Online) Ano de publicação: 2020 Tipo de documento: Article
Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Anim. Reprod. / Anim. Reprod. (Online) Ano de publicação: 2020 Tipo de documento: Article