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Spectral analysis, in vitro cytotoxicity and antibacterial studies of bioactive principles from the leaves of Conocarpus lancifolius, a common tree of Jazan, Saudi Arabia / Análise espectral, citotoxicidade in vitro e estudos antibacterianos de princípios bioativos das folhas de Conocarpus lancifolius, uma árvore comum de Jazan, Arábia Saudita
Moni, S. S; Alam, M. F; Sultam, M. H; Makeen, H. A; Alhazmi, H. A; Mohan, S; Alam, Md. S; Ur Rehman, Z; Jabeen, A; Sanobar, S; Elmobark, M. E; Siddiqui, R; Anwer, T.
Afiliação
  • Moni, S. S; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Alam, M. F; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
  • Sultam, M. H; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Makeen, H. A; Jazan University. College of Pharmacy. Clinical Pharmacy Department. Pharmacy Practice Research Unit. Jazan. SA
  • Alhazmi, H. A; Jazan University. Substance Abuse and Toxicology Research Centre. Jazan. SA
  • Mohan, S; Jazan University. Substance Abuse and Toxicology Research Centre. Jazan. SA
  • Alam, Md. S; Jazan University. College of Pharmacy. Department of Pharmaceutical Chemistry. Jazan. SA
  • Ur Rehman, Z; Jazan University. College of Pharmacy. Department of Pharmaceutical Chemistry. Jazan. SA
  • Jabeen, A; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Sanobar, S; Jazan University. College of Pharmacy. Department of Pharmacognosy. Jazan. SA
  • Elmobark, M. E; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Siddiqui, R; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
  • Anwer, T; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
Braz. j. biol ; 83: 1-10, 2023. ilus, graf, tab
Article em En | LILACS, VETINDEX | ID: biblio-1468841
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
The objective of the present study was to analyse the bioactive compounds of the leaves of Conocarpus lancifolius (C. lancifolius). The GC-MS analysis of the hot methanolic extract of the leaves (HMEL) of C. lancifolius exhibited the bioactive compounds such as 1-(3-Methoxy-2-nitrobenzyl) iso quinoline, morphin-4-ol-6,7-dione, 1-bromo N-methyl-, phytol, hexadecanoic acid, 2,3-dihydroxypropyl ester, 2,2’4’,2”-terthiophene, ethyl iso-allocholate, caryophyllene oxide, campesterol, epiglobulol, cholestan-3-ol, 2-methylene-, (3á,5à)-, dasycarpidan-1-methanol, acetate (ester) and oleic acid, eicosyl ester. The FT-IR analysis of HMEL of C. lancifolius showed a unique peak at 3184, 2413, 1657 cm-¹ representing coumaric acid, chlorogenic acid and ferulic acid. The HMEL of C. lancifolius was actively inhibiting the proliferation of breast cancer cells MCF-7 ATCC at the concentration of 72.66 ± 8.21 µg/ml as IC50 value. The HMEL of C. lancifolius also revealed a good spectrum of activity against Gram-positive and Gram negative bacterial cultures screened in this work. The activity observed has shown more or less similar effects against screened bacteria. However, the magnitude of potentiality was significantly lesser compared to standard ciprofloxacin disc at p< 0.001 level (99% confidence intervals). Furthermore, the study demonstrating the bioactive compounds can be isolated from the leaves of C. lancifolius.
RESUMO
O objetivo do presente estudo foi analisar os compostos bioativos das folhas de Conocarpus lancifolius (C. lancifolius). A análise por GC-MS do extrato metanólico quente das folhas (HMEL) de C. lancifolius exibiu os compostos bioativos como 1- (3-Metoxi-2-nitrobenzil) isoquinolina, morfina-4-ol-6,7- diona, 1-bromo-N-metil-, fitol, ácido hexadecanoico, 2,3-di-hidroxipropil éster, 2,2 ‘ 4’, 2 ” - tertiofeno, isoalocolato de etil, óxido de cariofileno, campesterol, epiglobulol, colestano -3-ol, 2-metileno-, (3á, 5à) -, dasycarpidan-1-metanol, acetato (éster) e ácido oleico, éster eicosílico. A análise FT-IR de HMEL de C. lancifolius mostrou um pico único em 3184, 2413, 1657 cm-¹ representando ácido cumarico, ácido clorogênico e ácido ferúlico. O HMEL de C. lancifolius inibiu ativamente a proliferação de células de câncer de mama MCF-7 ATCC na concentração de 72,66 ± 8,21 µg/ml como valor de IC50. O HMEL de C. lancifolius também revelou bom espectro de atividade contra culturas de bactérias Gram-positivas e Gram-negativas rastreadas neste trabalho. A atividade observada mostrou efeitos mais ou menos semelhantes contra bactérias rastreadas. No entanto, a magnitude da potencialidade foi significativamente menor em comparação com o disco de ciprofloxacina padrão em nível de p < 0,001 (intervalos de confiança de 99%). Além disso, o estudo demonstrando os compostos bioativos pode ser isolado das folhas de C. lancifolius.
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Texto completo: 1 Base de dados: VETINDEX / LILACS Idioma: En Revista: Braz. J. Biol. / Braz. j. biol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX / LILACS Idioma: En Revista: Braz. J. Biol. / Braz. j. biol Ano de publicação: 2023 Tipo de documento: Article