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Learning and survival memory undergoing a permanent bilateral carotid ligation in rats
Melo, Maria Cecília Santos Cavalcanti; Gadelha, Diego; Mascena, Guilherme Veras; Oliveira, Thárcia Kiara Beserra; Brandt, Carlos Teixeira.
Afiliação
  • Melo, Maria Cecília Santos Cavalcanti; Faculdade de Ciências Médicas. Departamento de Oftalmologia. Campina Grande. Brasil
  • Gadelha, Diego; Faculdade de Ciências Médicas. Departamento de Oftalmologia. Campina Grande. Brasil
  • Mascena, Guilherme Veras; Faculdade de Ciências Médicas. Departamento de Oftalmologia. Campina Grande. Brasil
  • Oliveira, Thárcia Kiara Beserra; Faculdade de Ciências Médicas. Departamento de Oftalmologia. Campina Grande. Brasil
  • Brandt, Carlos Teixeira; Faculdade de Ciências Médicas. Departamento de Oftalmologia. Campina Grande. Brasil
Acta cir. bras. ; 28(2): 102-105, 2013. graf
Article em En | VETINDEX | ID: vti-8956
Biblioteca responsável: BR1.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL).

METHODS:

Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation.

RESULTS:

The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal 10.24 ± 1.85s - Study 25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals.

CONCLUSION:

The permanent bilateral carotid ligation induces change in the learning and survival memory.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2013 Tipo de documento: Article