Effect of copaiba oil in hepatic damage induced by acetaminophen in rats
Teixeira, Renan Kleber Costa; Yamaki, Vitor Nagai; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques.
Acta cir. bras.;
28(7): 526-530, July 2013. tab
Artigo
em Inglês
| VETINDEX
| ID: vti-9012
Resumo
PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase,

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