Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Integration of Î¶-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells.

Kath, Jonas; Franke, Clemens; Drosdek, Vanessa; Du, Weijie; Glaser, Viktor; Fuster-Garcia, Carla; Stein, Maik; Zittel, Tatiana; Schulenberg, Sarah; Porter, Caroline E; Andersch, Lena; Künkele, Annette; Alcaniz, Joshua; Hoffmann, Jens; Abken, Hinrich; Abou-El-Enein, Mohamed; Pruß, Axel; Suzuki, Masataka; Cathomen, Toni; Stripecke, Renata; Volk, Hans-Dieter; Reinke, Petra; Schmueck-Henneresse, Michael; Wagner, Dimitrios Laurin.

Blood ; 2024 Mar 17.

Artigo em Inglês | MEDLINE | ID: mdl-38493479

2.

Costimulation Engages the Gear in Driving CARs.

Abken, Hinrich.

Immunity ; 44(2): 214-6, 2016 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-26885852

3.

IL12 integrated into the CAR exodomain converts CD8⁺ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors.

Hombach, Andreas; Barden, Markus; Hannappel, Lisa; Chmielewski, Markus; Rappl, Gunter; Sachinidis, Agapios; Abken, Hinrich.

Mol Ther ; 30(2): 593-605, 2022 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-34678512

4.

Engineering T-cells with chimeric antigen receptors to combat hematological cancers: an update on clinical trials.

Ormhøj, Maria; Abken, Hinrich; Hadrup, Sine R.

Cancer Immunol Immunother ; 71(10): 2301-2311, 2022 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-35199207

5.

Treatment with Living Drugs: Pharmaceutical Aspects of CAR T Cells.

Holzinger, Astrid; Abken, Hinrich.

Pharmacology ; 107(9-10): 446-463, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35696994

6.

A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells.

Garofano, Francesca; Sharma, Amit; Abken, Hinrich; Gonzalez-Carmona, Maria A; Schmidt-Wolf, Ingo G H.

Int J Mol Sci ; 23(7)2022 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-35409142

7.

[CAR T cells as drugs for novel therapies (advanced therapy medicinal products)]. / CAR-T-Zellen als Arzneimittel für neuartige Therapien (Advanced Therapy Medicinal Products).

Köhl, Ulrike; Abken, Hinrich.

Internist (Berl) ; 62(4): 449-457, 2021 Apr.

Artigo em Alemão | MEDLINE | ID: mdl-33590292

8.

Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells.

Haumann, Sophie; Boix, Julia; Knuever, Jana; Bieling, Angela; Vila Sanjurjo, Anton; Elson, Joanna L; Blakely, Emma L; Taylor, Robert W; Riet, Nicole; Abken, Hinrich; Kashkar, Hamid; Hornig-Do, Hue-Tran; Wiesner, Rudolf J.

Carcinogenesis ; 41(12): 1735-1745, 2020 12 31.

Artigo em Inglês | MEDLINE | ID: mdl-32255484

9.

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4⁺ T cells to reduce the latent HIV⁺ cell reservoir.

Patasic, Lea; Seifried, Janna; Bezler, Valerie; Kaljanac, Marcell; Schneider, Irene C; Schmitz, Heike; Tondera, Christiane; Hartmann, Jessica; Hombach, Andreas; Buchholz, Christian J; Abken, Hinrich; König, Renate; Cichutek, Klaus.

Med Microbiol Immunol ; 209(6): 681-691, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-32918599

10.

Advances and Challenges of CAR T Cells in Clinical Trials.

Holzinger, Astrid; Abken, Hinrich.

Recent Results Cancer Res ; 214: 93-128, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31473850

11.

Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30^- Tumors.

Hombach, Andreas A; Rappl, Gunter; Abken, Hinrich.

Mol Ther ; 27(10): 1825-1835, 2019 10 02.

Artigo em Inglês | MEDLINE | ID: mdl-31331813

12.

A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts.

Tóth, Gábor; Szöllosi, János; Abken, Hinrich; Vereb, György; Szöor, Árpád.

Int J Mol Sci ; 21(3)2020 Feb 04.

Artigo em Inglês | MEDLINE | ID: mdl-32033208

13.

Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function.

Probst, Kristina; Stermann, Jacek; von Bomhard, Inga; Etich, Julia; Pitzler, Lena; Niehoff, Anja; Bluhm, Björn; Xu, Haifeng C; Lang, Philipp A; Chmielewski, Markus; Abken, Hinrich; Blissenbach, Birgit; Machova, Alzbeta; Papadopoulou, Nikoletta; Brachvogel, Bent.

Stem Cells ; 36(11): 1752-1763, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30063808

14.

CD28-Î¶ CAR T Cells Resist TGF-ß Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop.

Golumba-Nagy, Viktória; Kuehle, Johannes; Hombach, Andreas A; Abken, Hinrich.

Mol Ther ; 26(9): 2218-2230, 2018 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-30055872

15.

CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin's Lymphoma and Multiple Myeloma.

Bluhm, Julia; Kieback, Elisa; Marino, Stephen F; Oden, Felix; Westermann, Jörg; Chmielewski, Markus; Abken, Hinrich; Uckert, Wolfgang; Höpken, Uta E; Rehm, Armin.

Mol Ther ; 26(8): 1906-1920, 2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-30078440

16.

Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform.

Aleksandrova, Krasimira; Leise, Jana; Priesner, Christoph; Melk, Anette; Kubaink, Fanni; Abken, Hinrich; Hombach, Andreas; Aktas, Murat; Essl, Mike; Bürger, Iris; Kaiser, Andrew; Rauser, Georg; Jurk, Marion; Goudeva, Lilia; Glienke, Wolfgang; Arseniev, Lubomir; Esser, Ruth; Köhl, Ulrike.

Transfus Med Hemother ; 46(1): 47-54, 2019 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-31244581

17.

Chimeric antigen receptor T cells targeting Fc µ receptor selectively eliminate CLL cells while sparing healthy B cells.

Faitschuk, Elena; Hombach, Andreas A; Frenzel, Lukas P; Wendtner, Clemens-Martin; Abken, Hinrich.

Blood ; 128(13): 1711-22, 2016 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-27535994

18.

Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity.

Ligtenberg, Maarten A; Mougiakakos, Dimitrios; Mukhopadhyay, Madhura; Witt, Kristina; Lladser, Alvaro; Chmielewski, Markus; Riet, Tobias; Abken, Hinrich; Kiessling, Rolf.

J Immunol ; 196(2): 759-66, 2016 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-26673145

19.

Nanobody Based Dual Specific CARs.

De Munter, Stijn; Ingels, Joline; Goetgeluk, Glenn; Bonte, Sarah; Pille, Melissa; Weening, Karin; Kerre, Tessa; Abken, Hinrich; Vandekerckhove, Bart.

Int J Mol Sci ; 19(2)2018 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-29385713

20.

Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma.

Chmielewski, Markus; Hombach, Andreas A; Abken, Hinrich.

Immunol Rev ; 257(1): 83-90, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24329791

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