Detalhe da pesquisa
1.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrob Agents Chemother
; 66(1): e0158421, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694880
2.
An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2.
Toxicol Appl Pharmacol
; 443: 116006, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367236
3.
Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction.
Drug Metab Dispos
; 48(6): 481-490, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32193358
4.
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
Malar J
; 19(1): 1, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898492
5.
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
Pharm Res
; 35(11): 210, 2018 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30225649
6.
Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.
J Pharmacokinet Pharmacodyn
; 45(5): 747-762, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30218416
7.
Randomized, placebo-controlled, double-blind phase I trial of co-administered pyronaridine and piperaquine in healthy adults of sub-Saharan origin.
Clin Transl Sci
; 17(4): e13738, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38594824
8.
Development and application of a PBPK modeling strategy to support antimalarial drug development.
CPT Pharmacometrics Syst Pharmacol
; 12(9): 1335-1346, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37587640
9.
Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.
Clin Pharmacol Ther
; 111(4): 867-877, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34453327
10.
Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial.
EBioMedicine
; 86: 104322, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36332361
11.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Nat Commun
; 13(1): 2158, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35444200
12.
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.
ACS Infect Dis
; 7(7): 1885-1893, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34101429
13.
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
J Pharmacol Exp Ther
; 325(3): 859-68, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364470
14.
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.
PLoS Negl Trop Dis
; 11(9): e0005942, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28934207
15.
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.
ACS Med Chem Lett
; 8(12): 1304-1308, 2017 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29259752
16.
Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin.
J Control Release
; 108(2-3): 319-30, 2005 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16169627
17.
Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility.
J Pharm Sci
; 94(12): 2667-75, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16258982
18.
Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies.
Front Immunol
; 5: 233, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904582
19.
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
ACS Med Chem Lett
; 4(11): 1037-41, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900603
20.
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.
J Med Chem
; 54(20): 7299-317, 2011 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21916510