Detalhe da pesquisa
1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
2.
Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.
PLoS Comput Biol
; 19(12): e1011662, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055683
3.
Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Clin Infect Dis
; 77(6): 857-865, 2023 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37161721
4.
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-Infected Patients Without Cirrhosis: OMEGA-1.
Hepatology
; 69(6): 2349-2363, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30693573
5.
Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients.
Br J Clin Pharmacol
; 82(1): 227-37, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27334415
6.
Pharmacokinetics of treosulfan in pediatric patients undergoing hematopoietic stem cell transplantation.
Ther Drug Monit
; 36(4): 465-72, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24487253
7.
Model-based meta-analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B-infected mice.
CPT Pharmacometrics Syst Pharmacol
; 13(5): 729-742, 2024 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522000
8.
Model-Informed Clinical Development of Once-Every-6-Month Injection of Paliperidone Palmitate in Patients with Schizophrenia: A Pharmacometric Bridging Approach (Part I).
Eur J Drug Metab Pharmacokinet
; 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38750386
9.
Model-Informed Clinical Development of 6-Monthly Injection of Paliperidone Palmitate in Patients with Schizophrenia: Dosing Strategies Guided by Population Pharmacokinetic Modeling and Simulation (Part II).
Eur J Drug Metab Pharmacokinet
; 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38769284
10.
Efficacy and safety exposure-response relationships of apalutamide in patients with metastatic castration-sensitive prostate cancer: results from the phase 3 TITAN study.
Cancer Chemother Pharmacol
; 89(5): 629-641, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35366072
11.
Population Pharmacokinetic Analysis of Darunavir and Tenofovir Alafenamide in HIV-1-Infected Patients on the Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Single-Tablet Regimen (AMBER and EMERALD Studies).
AAPS J
; 23(4): 82, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34100149
12.
Population Pharmacokinetics of Apalutamide and its Active Metabolite N-Desmethyl-Apalutamide in Healthy and Castration-Resistant Prostate Cancer Subjects.
Clin Pharmacokinet
; 59(2): 229-244, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31432469
13.
Efficacy and Safety Exposure-Response Relationships of Apalutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer.
Clin Cancer Res
; 26(17): 4460-4467, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32561663
14.
The AAPS Journal Theme Issue: "Perspectives on Clinical Drug Development of Long-Acting Injectables".
AAPS J
; 25(6): 104, 2023 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37963990
15.
Population Pharmacokinetics of AL-335 and Its Two Main Metabolites (ALS-022399, ALS-022227) in Monotherapy and in Combination with Odalasvir and/or Simeprevir.
AAPS J
; 21(1): 1, 2018 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30377854
16.
Characterizing the Pharmacokinetic Interaction Between Simeprevir and Odalasvir in Healthy Volunteers Using a Population Modeling Approach.
AAPS J
; 20(6): 111, 2018 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30350297
17.
Pharmacokinetic-pharmacodynamic modeling of the antihypertensive effect of eprosartan in Black and White hypertensive patients.
Clin Pharmacokinet
; 52(9): 793-803, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23696281
18.
Nonlinear mixed effects modeling of the diurnal blood pressure profile in a multiracial population.
Am J Hypertens
; 26(9): 1103-13, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23939415
19.
The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis.
J Pharm Sci
; 100(7): 2996-3009, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21283984
20.
Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro.
J Pharm Sci
; 99(1): 275-85, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19718740