Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model.

Accurate prognostic tools are crucial to assess the risk/benefit ratio of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with myelofibrosis (MF). We aimed to evaluate the performance of the Myelofibrosis Transplant Scoring System (MTSS) and identify risk factors for survival in a multicenter series of 197 patients with MF undergoing allo-HCT. After a median follow-up of 3.1 years, 47% of patients had died, and the estimated 5-year survival rate was 51%. Projected 5-year risk of nonrelapse mortality and relapse incidence was 30% and 20%, respectively. Factors independently associated with increased mortality were a hematopoietic cell transplantation-specific comorbidity index (HCT-CI) ≥3 and receiving a graft from an HLA-mismatched unrelated donor or cord blood, whereas post-transplant cyclophosphamide (PT-Cy) was associated with improved survival. Donor type was the only parameter included in the MTSS model with independent prognostic value for survival. According to the MTSS, 3-year survival was 62%, 66%, 37%, and 17% for low-, intermediate-, high-, and very high-risk groups, respectively. By pooling together the low- and intermediate-risk groups, as well as the high- and very high-risk groups, we pinpointed 2 categories: standard risk and high risk (25% of the series). Three-year survival was 62% in standard-risk and 25% in high-risk categories (P < .001). We derived a risk score based on the 3 independent risk factors for survival in our series (donor type, HCT-CI, and PT-Cy). The corresponding 5-year survival for the low-, intermediate-, and high-risk categories was 79%, 55%, and 32%, respectively (P < .001). In conclusion, the MTSS model failed to clearly delineate 4 prognostic groups in our series but may still be useful to identify a subset of patients with poor outcome. We provide a simple prognostic scoring system for risk/benefit considerations before transplantation in patients with MF.

[CHILD'S LIFESTYLE BEHAVIOURS RELATING TO WEIGHT AND MATERNAL SELF-EFFICACY IN MANAGING THEM]. / CONDUCTAS DEL ESTILO DE VIDA DEL HIJO RELACIONADAS CON EL PESO Y AUTOEFICACIA MATERNA PARA MANEJARLAS.

INTRODUCTION: parenting represents challenges. Mothers of overweight (OW) - obesity (OB) children face their children's lifestyle behaviors related to body weight. OBJECTIVES: 1) To assess the reliability of The Lifestyle Behaviour Checklist (LBC) in Spanish, 2) To evaluate the children's lifestyle behaviour that represent for the mother a problem for managing (PB) and self-efficacy (SE) to manage them in mothers of children with and without OW-OB and 3) To verify the differences between groups. METHODS: participated 367 dyads (mother / child). Mothers answered the LBC with two scales, problems behaviour scale (PBS) and self-efficacy to managing them scale (SMS). The dyads' weight and size were measured. Cronbach's alpha coefficient, descriptive statistics and ANOVA were calculated. RESULTS: Cronbach's alpha for PBS was 0.86 and 0.96 for SMS. Watches too much television was the greatest problem in managing for mothers of children with and without OW-OB (F = .232, p = .630). The mothers of children with OW-OB had lower self-efficacy compared to mothers of children without OW-OB (F = 14,155, p = .001). The mothers of children with OW-OB perceived more PB (Mean = 55.40) and less SE compared to mothers of children without OW-OB (F = 15.45, p.

Introducción: la crianza de los hijos representa retos. Las madres de hijos con sobrepeso (SP) - obesidad (OB) enfrentan conductas del estilo de vida del hijo (CEVH) relacionadas con el peso corporal. Objetivos: 1) Evaluar la confiabilidad de la escala Lista de Verificación de CEVH (LVC) en Español. 2) Evaluar las CEVH que representan un problema para su manejo (PC) y la autoeficacia (AE) para manejarlos, en madres de hijos con y sin SP-OB y 3) Verificar diferencias entre los grupos. Métodos: participaron 367 diadas (madre/hijo). Las madres contestaron la Escala LVC con dos escalas: escala problemas de conductua (EPC) y escala autoeficacia para manejarlos (EAE). Se midió peso y talla a las diadas. Se obtuvó coeficiente alpha de Cronbach, estadísticas descriptivas y se aplicó ANOVA. Resultados: el alpha de Cronbach para la EPC fue 0,86 y para la EAE 0,96. Ver mucha televisión fue el mayor PC que las madres de hijos con y sin SP-OB tienen que manejar (F = ,232, p = ,630). Las madres de hijos con SP-OB tuvieron menor AE respecto a las madres de hijos sin SP-OB (F = 14,155, p = ,001). Las madres de hijos con SP-OB percibieron más PC (media = 55,40) y tuvieron menor AE respecto a las madres de hijos sin SP-OB (F = 15,45, p < ,001). Conclusiones: la Escala LVC en Español mostró una consistencia interna aceptable. Las madres de hijos con SP-OB percibieron más PC y tuvieron menor AE. Se recomienda implementar programas para fortalecer la AE materna.