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1.
Phys Chem Chem Phys ; 26(3): 2486-2496, 2024 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-38170642

RESUMO

We investigate the spectral and temporal atomic coherence interaction based on out-of-phase fluorescence (FL) and spontaneous parametric four-wave mixing (SFWM) from the hexagonal phase of Eu3+ : NaYF4 and different phases of Eu3+ : BiPO4. Spectral and temporal interactions are interrelated and reduced by about 2 times due to two-photon nested dressing in contrast to the sum of each laser excitation. As the lifetime of photons increases, off-resonance profile cross-interaction decreases because cross-interaction reverses the signal at the near time gate position and keeps it consistent at the far time gate position. Moreover, the thermal phonon dressing at 300 K exhibits 6 times more eminent and obvious temporal interaction than that at 77 K. In a different phase of Eu3+ : BiPO4, there are three dark dips having stronger self-interaction; however, Eu3+ : NaYF4 has two dark dips as Eu3+ : BiPO4 has two phonon dressing. Further, the pure hexagonal phase of Eu3+ : BiPO4 demonstrates the strongest cross-interaction and longest coherent time under the dressing effect due to the smallest dressing phonon detuning and off-resonance profile cross-interaction at PMT2 because the angle quantization is the strongest. Such results can be used for designing novel quantum devices and have potential applications in quantum memory devices.

2.
Small ; : e2309029, 2023 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-38037486

RESUMO

Layered oxides are widely used as the electrode materials for metal ion batteries. However, for large radius size ions, such as Zn2+ and Al3+ , the tightly stacked layers and poor electrical conductivity of layered oxides result in restricted number of active sites and sluggish reaction kinetics. In this work, a facile in-situ construction strategy is provided to synthesize layered oxide nanosheets/nitrogen-doped carbon nanosheet (NC) heterostructure, which shows larger interlayer spacing and better electrical conductivity than the layered oxides. As a result, the Zn2+ ion diffusion inside the interlayer gallery is greatly enhanced and the storage sites inside the gallery can be better used. Meanwhile, the NC layers and oxide nanosheets are bridged by the C─O bonds to form a stable structure, which contributes to a better cycling stability than the pure layered oxides. The optimal V2 O5 @NC-400 cathode shows a capacity of 467 mA h g-1 at 0.1 A g-1 for 300 cycles, and long-term cyclic stability of 4000 cycles at 5 A g-1 with a capacity retention of 92%. All these performance parameters are among the best for vanadium oxide-based cathode materials.

3.
Bipolar Disord ; 25(1): 56-65, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36409044

RESUMO

BACKGROUND: The use of lithium during breast-feeding has not been comprehensively investigated in humans due to concerns about lithium toxicity. PROCEDURE: We analyzed lithium in the kidneys of nursed pups of lithium medicated mothers, using analytical spectroscopy in a novel rat model. The mothers were healthy rats administered lithium via gavage (1000 mg/day Li2 CO3 per 50 kg body weight). RESULTS: Lithium was detected in the breast milk, and in the blood of pups (0.08 mM), of lithium-exposed dams at post-natal day 18 (P18), during breast-feeding. No lithium was detected after breast-feeding, at P25 (4 days after cessation of nursing). The lithium pups blood had elevated urea nitrogen at P18 and reduced total T4 at P18 and P25, indicating a longer-term effect on the kidneys and the thyroid gland. Multivariate machine-learning analysis of spectroscopy data collected from the excised kidneys of pups showed elevated potassium in lithium-exposed animals both during- and after breast-feeding. The elevated renal potassium was associated with low nephrin expression in the kidneys measured immunohistochemically during breast-feeding. After lithium exposure is stopped, the filtration of lithium from the kidneys reverses these effects. Our study showed that breastfeeding during lithium use has an effect on the kidneys of the offspring in rats.


Assuntos
Transtorno Bipolar , Leite Humano , Feminino , Ratos , Lactente , Humanos , Animais , Leite Humano/química , Lítio/uso terapêutico , Transtorno Bipolar/tratamento farmacológico , Rim , Potássio/análise , Potássio/uso terapêutico , Aleitamento Materno
4.
Vascular ; 31(2): 369-374, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34958621

RESUMO

OBJECTIVES: This article aims to present a prospective study investigating the safety and efficacy of the Mynx Control extravascular closure device (Cordis Corporation, FL, USA), for femoral arterial closure in patients undergoing peripheral arterial procedures. METHODS: Between January 2020 and February 2021, 100 Mynx Control devices were deployed in 91 consecutive patients (mean age: 67.5 ± 16.9 years) who underwent peripheral arterial procedures. We used ultrasound and/or fluoroscopy during Mynx Control deployment and ultrasound post-procedure to detect complications. Femoral artery punctures included 62 (62%) antegrade and 38 (38%) retrograde punctures. The mean activated clotting time at time of device deployment was 221s. The primary endpoints were technical success, device failure, and complication rates up to 30 days. RESULTS: A 5F vascular sheath was used in 43 cases (43%) (36 (36%) 6F and 21 (21%) 7F). The majority of our cases had antegrade access (62%). Overall technical success rate was 97% in both antegrade and retrograde cases. In total, there were 4 minor complications: 3 (3%) cases of pseudoaneurysm and 1 (1%) case of haematoma. No major complications were recorded post-procedure or 30 days post index procedure. CONCLUSION: The Mynx Control vascular closure device is safe and effective in achieving haemostasis in patients undergoing antegrade and retrograde peripheral angioplasty procedures.


Assuntos
Dispositivos de Oclusão Vascular , Humanos , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Estudos Prospectivos , Técnicas Hemostáticas/efeitos adversos , Artéria Femoral/diagnóstico por imagem , Artéria Femoral/cirurgia , Resultado do Tratamento , Desenho de Equipamento , Estudos Retrospectivos
5.
Sensors (Basel) ; 23(8)2023 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-37112457

RESUMO

The emergence of the Internet of Things (IoT) technology has brought about tremendous possibilities, but at the same time, it has opened up new vulnerabilities and attack vectors that could compromise the confidentiality, integrity, and availability of connected systems. Developing a secure IoT ecosystem is a daunting challenge that requires a systematic and holistic approach to identify and mitigate potential security threats. Cybersecurity research considerations play a critical role in this regard, as they provide the foundation for designing and implementing security measures that can address emerging risks. To achieve a secure IoT ecosystem, scientists and engineers must first define rigorous security specifications that serve as the foundation for developing secure devices, chipsets, and networks. Developing such specifications requires an interdisciplinary approach that involves multiple stakeholders, including cybersecurity experts, network architects, system designers, and domain experts. The primary challenge in IoT security is ensuring the system can defend against both known and unknown attacks. To date, the IoT research community has identified several key security concerns related to the architecture of IoT systems. These concerns include issues related to connectivity, communication, and management protocols. This research paper provides an all-inclusive and lucid review of the current state of anomalies and security concepts related to the IoT. We classify and analyze prevalent security distresses regarding IoT's layered architecture, including connectivity, communication, and management protocols. We establish the foundation of IoT security by examining the current attacks, threats, and cutting-edge solutions. Furthermore, we set security goals that will serve as the benchmark for assessing whether a solution satisfies the specific IoT use cases.

6.
Vasa ; 52(1): 63-70, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36464999

RESUMO

Background: Haemodialysis access thrombosis is associated with significant morbidity and access abandonment rates, for which endovascular salvage is a well described treatment option. This study aimed to evaluate the outcomes of endovascular salvage procedures of thrombosed vascular access circuits and identify factors influencing outcomes. Patients and methods: Retrospective review of 328 consecutive procedures performed over 10 years at our institution between January 2010 and December 2019. Patient demographics, access circuit characteristics, procedure details and outcome data were collected. Kaplan-Meier survival curves were used to estimate patency rates and Cox multivariate regression analysis to identify factors affecting outcomes. Results: Technical and clinical success rates were 87.8% and 75.9% respectively. The primary, primary assisted and secondary patency rates at 6 months were 42.2%, 46.7% and 59.1%; and at 12 months were 23.4%, 28.3% and 41.8% respectively. Median access circuit survival was 9.2 months. Major complication rate was 5.2% including 3 procedure-related deaths. Native AVF, lower time from thrombosis to intervention and pharmacomechanical thrombectomy using AngioJetTM predicted positive outcomes. Previous thrombectomy within 3 months and residual thrombus at completion were associated with poorer outcomes. Age and hypertension predicted higher complication rates. Conclusions: This is one of the largest single center series of endovascular salvage of thrombosed haemodialysis access and demonstrates that endovascular treatment is effective and provides durable access circuit survival. Careful patient screening is essential to optimize outcomes.


Assuntos
Derivação Arteriovenosa Cirúrgica , Trombose , Humanos , Oclusão de Enxerto Vascular/diagnóstico por imagem , Oclusão de Enxerto Vascular/etiologia , Oclusão de Enxerto Vascular/cirurgia , Grau de Desobstrução Vascular , Derivação Arteriovenosa Cirúrgica/efeitos adversos , Resultado do Tratamento , Trombose/diagnóstico por imagem , Trombose/etiologia , Trombose/cirurgia , Trombectomia/efeitos adversos , Trombectomia/métodos , Diálise Renal/efeitos adversos , Estudos Retrospectivos
7.
HPB (Oxford) ; 25(4): 446-453, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36775699

RESUMO

OBJECTIVE: This survey sought to appraise the degree of consistency in the management of disappeared colorectal liver metastases (dCRLM) among liver surgeons in different countries. BACKGROUND: Colorectal liver metastases (CRLM) account for half of the deaths secondary to colorectal cancer. Due to the high utilization of chemotherapy before surgery, some or all CRLM can disappear (dCRLM) but management of dCRLMs remains unclear. METHODS: Seven simulated scenarios of dCRLM were presented to experienced liver surgeons using an online platform. Treatment decisions were submitted and analysed using the multi-rater kappa method. The effect of the experience, complexity of scenarios, and location and number of dCRLM on treatment decision were analysed. RESULTS: Sixty-seven liver surgeons from 25 countries completed the survey. There was no agreement about the therapeutic strategies of dCRLM in all scenarios (kappa 0.12, IQR 0.20-0.32). In scenarios with lower difficulty scores, surgeons tended to offer surgical resection for dCRLM alongside the visible CRLM (vCRLM), however, with poor agreement (kappa 0.32, IQR 0.19-0.51). No agreement was seen for clinical scenario in which all CRLM lesions disappeared (kappa 0.20). CONCLUSION: There are clear inconsistencies in the management decisions of dCRLM. Better evidence is required to define optimal management strategies.


Assuntos
Neoplasias Colorretais , Neoplasias Hepáticas , Humanos , Neoplasias Colorretais/terapia , Neoplasias Colorretais/patologia , Hepatectomia , Neoplasias Hepáticas/secundário , Inquéritos e Questionários
8.
Pak J Med Sci ; 39(3): 848-852, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37250559

RESUMO

Objective: To measure the efficacy and safety of surfactant administered by MIST and INSURE to neonates with respiratory distress syndrome. Methods: A randomized controlled trial was conducted from June 2021 to August 2022 at the NICU of the University of Child Health Sciences, Lahore. Neonates meeting inclusion criteria i.e with RDS who worsened on nasal Continuous positive airway pressure (nCPAP) (fiO2 30%, pressure 6cmH2O) were enrolled in the study in both interventional arms (MIST, n=36 and INSURE, n=36) using simple random sampling. Data was analysed using SPSS 25. Results: The mean age of neonates in MIST was 1.27±0.40 days and 1.23±0.48 days in INSURE cohort. Neonates with MIST (n=8) required statistically significant reduced need for IMV than INSURE (n=17) technique (P-Value 0.047). This study could not achieve significant difference in duration of mechanical ventilation (1±1.67; 1.52±1.40 days, P=0.152) and duration of nCPAP (3.27±1.65;3.67±1.64 hrs, P=0.312) in MIST versus INSURE. The second dose of surfactant was administered in fewer cases in MIST (n=2) than INSURE (n=7) (P=0.075). Risk estimation, although not significant, determined less likelihood for the pulmonary haemorrhage (0.908 than 1.095), intraventricular hemorrhage (0.657 than 1.353), administration of the second dose of surfactant (0.412 than 1.690) and greater likelihood of discharge (1.082 than 0.270) at 95% confidence interval with MIST technique. Conclusion: Surfactant therapy through MIST is effective and there is significantly reduced need of IMV than in INSURE. Safety profile though could not achieve statistical significance yet determines less risk of complications associated with MIST than INSURE.RCT Registration Number: TCTR20210627001.

9.
Br J Surg ; 109(6): 539-544, 2022 05 16.
Artigo em Inglês | MEDLINE | ID: mdl-35576389

RESUMO

BACKGROUND: Heterogeneity of outcomes is a problem for assessing intervention effectiveness when considering treatments for uncomplicated symptomatic gallstone disease. The value to all stakeholders of outcomes that have been measured and reported to date is also unclear. The aim of this study was to develop a core outcome set for symptomatic uncomplicated gallstone disease. METHODS: An in person-meeting was held with patients to prioritize potentially important outcomes from a previously developed longlist of outcomes. This was followed by an online three-round Delphi survey that was conducted with healthcare professionals. The results of each consensus process were compared and combined to produce the final core outcome set. RESULTS: A total of 82 participants enrolled in round 1 of the Delphi survey, with a final sample of 40 participants contributing to round 3. Five patients contributed to the in-person group meeting. Following the consensus processes, 11 outcomes were considered to be core by patients and healthcare professionals, and included in the core outcome set. These were: quality of life; overall health state; overall satisfaction; overall pain; common bile duct injury; biliary leak; haemorrhage; need for endoscopic retrograde cholangiopancreatography; intra-abdominal collections; admission/readmission for problems; and reoperation. CONCLUSION: A core outcome set for symptomatic uncomplicated gallstone disease has been developed with patients and healthcare professionals. Eleven outcomes across four key domains have been identified. These represent the minimum set of outcomes that should be reported in trials evaluating interventions for gallstone disease.


Assuntos
Colelitíase , Qualidade de Vida , Consenso , Técnica Delphi , Humanos , Avaliação de Resultados em Cuidados de Saúde/métodos , Projetos de Pesquisa , Resultado do Tratamento
10.
Arch Virol ; 167(3): 969-972, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35112200

RESUMO

Nematodes are abundant, but little is known about their viruses. In this study, we report a novel partitivirus isolated from the entomopathogenic nematode species Steinernema ceratophorum, named "Steinernema ceratophorum partitivirus 1" (ScPV-1). The complete genome of ScPV-1 comprises two dsRNA segments, dsRNA1 (2352 bp) and dsRNA2 (2196 bp). Each dsRNA contains a single open reading frame (ORF), encoding a putative RNA-dependent RNA polymerase (RdRp) and a coat protein (CP), respectively. The sequences of the RdRp and CP showed the highest similarity (47% and 33% identity, respectively) to Plasmopara viticola associated partitivirus 7 (PvAP-7). A multiple sequence alignment and phylogenetic analysis of the RdRp of ScPV-1 and other selected viruses indicated that ScPV-1 is a new member of the genus Betapartitivirus in the family Partitiviridae.


Assuntos
Nematoides , Vírus de RNA , Animais , Genoma Viral , Nematoides/genética , Filogenia , Vírus de RNA/genética , RNA Viral/genética
11.
Phys Chem Chem Phys ; 24(20): 12457-12464, 2022 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-35575282

RESUMO

We study the hybrid bound states in continuum (BIC) in time and spectral domain obtained from Eu3+/Pr3+ doped YPO4 and BiPO4 crystals. The spectral and time domain BIC originates from the interference between broadband fluorescence (FL) and narrowband super-florescence (SP-FWM) due to the dressing effect and crystal phase transition. We present a relationship between BIC and correlation and investigate two-mode and three-mode noise correlation/squeezing when the wavelength of the applied field is fixed at the bright state and dark state. In contrast to the BIC peak, we observe a switch and anti-bunching-like phenomenon at the BIC dip. We realize at the BIC peak point that correlation exhibits multi-oscillations and long coherence time in Pr3+:YPO4 in contrast with Eu3+:YPO4. Further, our two-mode intensity noise correlation experimental results suggest a controllable bandstop filter with an 80% bandwidth contrast and a dual-channel amplifier with an 89% amplitude contrast.

12.
Surg Endosc ; 36(7): 4685-4700, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35286471

RESUMO

BACKGROUND: Inguinal hernia has a lifetime incidence of 27% in men and 3% in women. Surgery is the recommended treatment, but there is no consensus on the best method. Open repair is most popular, but there are concerns about the risk of chronic groin pain. Laparoscopic repair is increasingly accepted due to the lower risk of chronic pain, although its recurrence rate is still unclear. The aim of this overview is to compare the risk of recurrence and chronic groin pain in laparoscopic versus open repair for inguinal hernia. METHODS: We searched Ovid MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews for systematic reviews and meta-analyses. Only reviews of randomised controlled trials (RCTs) in adults published in English were included. Conference proceedings and editorials were excluded. The quality of the systematic reviews was assessed using the AMSTAR 2 checklist. Two outcomes were considered: hernia recurrence and chronic pain. RESULTS: Twenty-one systematic reviews and meta-analyses were included. Laparoscopic repair was associated with a lower risk of chronic groin pain compared with open repair. In the four systematic reviews assessing any laparoscopic versus any open repairs, laparoscopic repair was associated with a statistically significant (range: 26-46%) reduction in the odds or risk of chronic pain. Most reviews showed no difference in recurrence rates between laparoscopic and open repairs, regardless of the types of repair considered or the types of hernia that were studied, but most reviews had wide confidence intervals and we cannot rule out clinically important effects favouring either type of repair. CONCLUSION: Meta-analyses suggest that laparoscopic repairs have a lower incidence of chronic groin pain than open repair, but there is no evidence of differences in recurrence rates between laparoscopic and open repairs.


Assuntos
Dor Crônica , Hérnia Inguinal , Laparoscopia , Adulto , Dor Crônica/etiologia , Dor Crônica/cirurgia , Hérnia Inguinal/complicações , Hérnia Inguinal/cirurgia , Herniorrafia/métodos , Humanos , Laparoscopia/métodos , Masculino , Dor Pós-Operatória/etiologia , Dor Pós-Operatória/cirurgia , Ensaios Clínicos Controlados Aleatórios como Assunto , Recidiva , Telas Cirúrgicas/efeitos adversos , Revisões Sistemáticas como Assunto
13.
Bipolar Disord ; 23(6): 615-625, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33507599

RESUMO

BACKGROUND: Lithium is especially taken as a maintenance medication for Bipolar Disorder. In women with bipolar disorder, lithium is often effective during postpartum period, but breast-feeding for medicated mothers is controversial because of harmful effects for her child. At present, the biological mechanisms of lithium are not well-understood, affecting its usage and overall health implications. PROCEDURE: We developed a rat lithium and breast-feeding model at human therapeutic levels to study the effects of lithium exposure through breast-milk on pups' thyroid function. Novel laser analytical spectroscopy, along with traditional blood and immunohistochemical tests, were applied to further investigate the mechanisms behind the thyroid dysfunction. Maternal iodine supplementation was evaluated as a therapeutic method to address the pups' thyroid dysfunction. RESULTS: Pups exposed to lithium via breastmilk, even with the dam on a sub-therapeutic level, experienced weight gain, reduced blood thyroxine (T4 ), and elevated blood urea nitrogen, indicating effects on thyroid and kidney function. We show that lithium inhibited iodine uptake by thyroid follicles, initiating a mechanism that reduced iodination of tyrosine, thyroglobulin cleavage, and thyroid hormone production. Importantly, infant thyroid function can be significantly improved by administering supplementary iodine to the medicated dam's diet during breast-feeding. CONCLUSION: These results elucidate the mechanisms of lithium in thyroid function, provide valuable information on use postpartum, and suggest a clinically applicable remedy to side-effects. The results are particularly important for patients (and their infants) who respond well to lithium and need, or choose, to breast-feed.


Assuntos
Transtorno Bipolar , Iodo , Animais , Suplementos Nutricionais , Feminino , Humanos , Iodo/análise , Lítio , Leite Humano , Ratos , Glândula Tireoide/diagnóstico por imagem , Tireotropina
14.
Analyst ; 146(16): 5186-5197, 2021 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-34297019

RESUMO

Lithium salts are commonly used as medication for Bipolar Disorder (BD) and depression. However, there are limited methods to quantify intracellular lithium. Most methods to analyze intracellular electrolytes require tedious sample processing, specialized and often expensive machinery, sometimes involving harmful chemicals, and a bulk amount of the sample. In this work, we report a novel method (FROZEN!) based on cell isolation (from the surrounding medium) through rapid de-ionized water cleaning, followed by flash freezing for preservation. SKOV3 cells were cultured in normal medium and a medium containing 1.0 mM lithium. Lithium and other intracellular electrolytes in the isolated and preserved cells were simultaneously analyzed with laser-induced breakdown spectroscopy (LIBS) and X-ray fluorescence spectroscopy (XRF). Key electrolytes such as sodium, potassium, and magnesium, along with lithium, were detectable at the single-cell level. We found that cells cultured in the lithium medium have an intracellular lithium concentration of 0.5 mM. Concurrently, the intracellular concentrations of other positively charged electrolytes (sodium, potassium, and magnesium) were reduced by the presence of lithium. FROZEN! will greatly facilitate research in intracellular electrolyte balance during drug treatment, or other physiological stresses. In particular, the cell isolation and preservation steps can be easily performed by many laboratories worldwide, after which the samples are sent to an analytical laboratory for electrolyte analysis.


Assuntos
Eletrólitos , Lítio , Animais , Congelamento , Potássio , Sódio
15.
J Hand Surg Am ; 46(3): 200-208, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33663695

RESUMO

PURPOSE: Wrist fusion provides a solution to the painful, arthritic wrist, and can be concomitantly performed with or without a proximal row carpectomy (PRC). The benefits of combining a PRC with fusion include a large amount of local bone graft for fusion and a lower number of joints needed to fuse. We hypothesized that wrist fusion combined with PRC will have a higher fusion rate than wrist fusion performed without PRC. METHODS: A systematic review was performed to identify all papers involving wrist arthrodesis using the following databases: PubMed, Ovid, Scopus, Web of Science, and COCHRANE. A literature search was performed using the phrases "wrist" OR "radiocarpal" and "fusion" OR "arthrodesis". Inclusion criteria included complete radiocarpal fusion performed for rheumatoid, posttraumatic, or primary arthritis; union rates available; English-language study. Studies were excluded if case reports; diagnoses other than the ones listed previously; inability to abstract the data. Data collected included wrist fusions with PRC or without PRC, union rate, patient age, underlying diagnosis, and method of fixation. RESULTS: A total of 50 studies were included in the analysis. There were 41 studies with no PRC, 8 studies with PRC, and 1 study with and without PRC. There were 347 patients with a PRC and 339 patients had a successfully fused wrist (97.7%). There were 1,355 patients who had a wrist fusion with no PRC, and1,303 patients had successful wrist fusion (96.2%). The difference in fusion rate between the 2 groups, 97.7% versus 96.2%, was not statistically significant. CONCLUSIONS: There is no statistically significant difference with regards to union rate in wrist fusion with a PRC versus wrist fusion without a PRC. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.


Assuntos
Ossos do Carpo , Artrodese , Ossos do Carpo/cirurgia , Humanos , Amplitude de Movimento Articular , Resultado do Tratamento , Punho , Articulação do Punho/cirurgia
16.
J Shoulder Elbow Surg ; 30(7): 1647-1652, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33373682

RESUMO

BACKGROUND: Distal biceps ruptures are rare injuries that tend to occur at a younger age in high-level athletic populations. Data analyzing athletes' ability to return to play, as well as performance, after surgery for a distal biceps rupture are lacking. METHODS: All National Football League (NFL) players from the 2000-2016 seasons who were found to have a surgically treated distal biceps rupture were included. Analysis of performance and career length was conducted with a control group matched for position, age, experience, and performance statistics. Data for the cohort vs. control group, as well as before vs. after injury, were analyzed with the paired-samples Student t test, with P < .05 deemed statistically significant. RESULTS: We identified 35 NFL players for the study; 33 (94%) were able to return to sport at an average of 351.4 ± 123.9 days. Offensive linemen undergoing surgery played fewer games per season compared with the control group (P = .04). However, the average number of seasons after surgery and after the index date was not found to be significant (P > .05). Mean career length, as well as number of games per season, did not differ in the postsurgical group vs. control group (P > .05) for all other positions. Performance scores within skill players did not prove to be significant between the postoperative and control groups (P > .05). CONCLUSIONS: Distal biceps ruptures treated surgically in NFL players allow for return to play at a high rate. The level of performance after surgery is similar to that of the player before injury. On average, NFL career length does not appear to be affected after distal biceps surgery.


Assuntos
Futebol Americano , Atletas , Estudos de Coortes , Humanos , Volta ao Esporte , Ruptura/cirurgia
17.
J Pak Med Assoc ; 71(5): 1486-1488, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34091641

RESUMO

The periampullary neuroendocrine tumour is an infrequently occurring tumour. Its prevalence among gastrointestinal neuroendocrine neoplasms is less than 0.3%, and less than 2% out of periampullary tumours. These neoplasms have relatively poor prognosis. Jaundice and pain in the abdomen are the early and most commonly occurring symptoms with weight loss being a late event. The carcinoid syndrome presents infrequently in periampullary neuroendocrine tumour and happens only if hepatic metastasis occurs. In this scenario, histopathology plays a paramount role in the diagnosis. Specific immunohistochemical staining is used for diagnosis while the treatment options are local excision, endoscopic excision and pancreaticoduodenectomy. Here is a case report of a 42-year-old patient who presented with complaint of obstructive jaundice for one month. Periampullary carcinoid tumour was diagnosed on biopsy, and she underwent Pancreaticoduodenectomy as treatment. Literature shows that there is poor precision of preoperative and intraoperative lymph node metastatic involvement regardless of the size of the tumour. Hence, radical resection must be considered the standard approach.


Assuntos
Ampola Hepatopancreática , Tumor Carcinoide , Neoplasias do Ducto Colédoco , Tumores Neuroendócrinos , Adulto , Ampola Hepatopancreática/cirurgia , Tumor Carcinoide/diagnóstico , Tumor Carcinoide/cirurgia , Neoplasias do Ducto Colédoco/diagnóstico , Neoplasias do Ducto Colédoco/cirurgia , Feminino , Humanos , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/cirurgia , Pancreaticoduodenectomia
18.
Trop Anim Health Prod ; 53(5): 508, 2021 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-34626253

RESUMO

Nanotechnology is the discipline and technology of small and specific things that are < 100 nm in size. Because of their extremely miniscule size, any changes in their chemical and physical structure may show higher reactivity and solubility than larger particles. Nanotechnology plays a vital role in every field of life. It is considered one of the most bleeding edge field of scientific research. It has already several applications in a myriad of disciplines while its application in the field of animal production and veterinary medicine is still experimental in nature. But, in recent years, the role of nanotechnology in the aforementioned fields of scientific inquiry has shown great progress. These days, nanotechnology has been employed to revolutionize drug delivery systems and diagnose atypical diseases. Applications of nanoparticle technology in the field of animal reproduction and development of efficacious vaccines have been at the forefront of scientific endeavors. Additionally, their impacts on meat and milk quality are also being judiciously inquired in recent decades. Veterinary nanotechnology has great potential to improve diagnosis and treatment, and provide new tools to this field. This review focuses on some noteworthy applications of nanoparticles in the field of animal production and their future perspectives.


Assuntos
Nanopartículas , Nanotecnologia , Animais , Sistemas de Liberação de Medicamentos/veterinária , Leite
19.
Opt Express ; 28(18): 26572-26586, 2020 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-32906934

RESUMO

Research on entangled multipartite systems with controllable wave functions has attracted significant interest in the field of quantum optics. For quantum communications and quantum information processing, linear and nonlinear optical susceptibilities govern high-order correlations and entangled multiple-photon resources. In single- and double-dressing quadphoton correlations, we have observed the evolution of linear and nonlinear optical responses in the group delay and Rabi oscillation regimes. In the group delay regime, when linear susceptibility is evident, the quadphoton coincidence counting rate exhibits a rectangular profile. In the Rabi oscillation regime, the enhanced nonlinear susceptibility induced by strong laser dressing effects control quadphoton wave packets based on damped Rabi oscillation. Additionally, at different delay times, some photons exist in the group delay regimes, while others exist in the Rabi oscillation regimes, suggesting a coexistence mechanism. Additionally, there is a transition regime in which a portion of the photons are in both the group delay and Rabi oscillation regimes. By varying the power of the dressing field and optical depth, we realized the evolution between these two regimes for entangled quadphotons. Additionally, we demonstrate the shortening of coherence times under double-dressing conditions compared to single-dressing conditions. These results can help improving the length of coherence time and information capacity, which have great significance for the future development of long-distance and long coherent time quantum communication and quantum storage.

20.
Arch Virol ; 165(12): 2979-2983, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32902666

RESUMO

To our knowledge, no mycoviruses have been reported in Fusarium cerealis. Here, we describe a novel double-stranded RNA (dsRNA) virus, Fusarium cerealis partitivirus 1 (FcPV1), isolated from F. cerealis strain HN30 from Henan Province, China. The FcPV1 genome consists of two dsRNA segments, 1732 bp (dsRNA1) and 1361 bp (dsRNA2) in length, each containing a single open reading frame potentially encoding a 61.0-kDa protein and a 42.0-kDa protein, respectively. dsRNA1 encodes a putative RNA-dependent RNA polymerase (RdRp), while the dsRNA2 product has no significant similarity to any other capsid proteins (CPs) in the GenBank databases other than limited similarity to hypothetical "capsid" proteins of a few partitiviruses. Sequence alignments and phylogenetic analysis showed that FcPV1 is related to members of the newly proposed genus "Zetapartitivirus" in the family Partitiviridae.


Assuntos
Micovírus/classificação , Fusarium/virologia , Genoma Viral , Filogenia , RNA de Cadeia Dupla/genética , Sequência de Aminoácidos , Proteínas do Capsídeo/genética , China , Micovírus/isolamento & purificação , Fases de Leitura Aberta , Doenças das Plantas/microbiologia , RNA Viral/genética , RNA Polimerase Dependente de RNA/genética , Alinhamento de Sequência
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