Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.

Milligan, Jacob C; Davis, Carl W; Yu, Xiaoying; Ilinykh, Philipp A; Huang, Kai; Halfmann, Peter J; Cross, Robert W; Borisevich, Viktoriya; Agans, Krystle N; Geisbert, Joan B; Chennareddy, Chakravarthy; Goff, Arthur J; Piper, Ashley E; Hui, Sean; Shaffer, Kelly C L; Buck, Tierra; Heinrich, Megan L; Branco, Luis M; Crozier, Ian; Holbrook, Michael R; Kuhn, Jens H; Kawaoka, Yoshihiro; Glass, Pamela J; Bukreyev, Alexander; Geisbert, Thomas W; Worwa, Gabriella; Ahmed, Rafi; Saphire, Erica Ollmann.

Cell ; 185(6): 995-1007.e18, 2022 03 17.

Artigo em Inglês | MEDLINE | ID: mdl-35303429

2.

Immunological lessons from CD28 deficiency in humans.

Wieland, Andreas; Ahmed, Rafi.

Cell ; 184(14): 3595-3597, 2021 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-34242561

3.

Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection.

Davis, Carl W; Jackson, Katherine J L; McElroy, Anita K; Halfmann, Peter; Huang, Jessica; Chennareddy, Chakravarthy; Piper, Ashley E; Leung, Yvonne; Albariño, César G; Crozier, Ian; Ellebedy, Ali H; Sidney, John; Sette, Alessandro; Yu, Tianwei; Nielsen, Sandra C A; Goff, Arthur J; Spiropoulou, Christina F; Saphire, Erica Ollman; Cavet, Guy; Kawaoka, Yoshihiro; Mehta, Aneesh K; Glass, Pamela J; Boyd, Scott D; Ahmed, Rafi.

Cell ; 177(6): 1566-1582.e17, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31104840

4.

Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.

Abadie, Kathleen; Clark, Elisa C; Valanparambil, Rajesh M; Ukogu, Obinna; Yang, Wei; Daza, Riza M; Ng, Kenneth K H; Fathima, Jumana; Wang, Allan L; Lee, Judong; Nasti, Tahseen H; Bhandoola, Avinash; Nourmohammad, Armita; Ahmed, Rafi; Shendure, Jay; Cao, Junyue; Kueh, Hao Yuan.

Immunity ; 57(2): 271-286.e13, 2024 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-38301652

5.

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies.

Chen, Yao-Qing; Wohlbold, Teddy John; Zheng, Nai-Ying; Huang, Min; Huang, Yunping; Neu, Karlynn E; Lee, Jiwon; Wan, Hongquan; Rojas, Karla Thatcher; Kirkpatrick, Ericka; Henry, Carole; Palm, Anna-Karin E; Stamper, Christopher T; Lan, Linda Yu-Ling; Topham, David J; Treanor, John; Wrammert, Jens; Ahmed, Rafi; Eichelberger, Maryna C; Georgiou, George; Krammer, Florian; Wilson, Patrick C.

Cell ; 173(2): 417-429.e10, 2018 04 05.

Artigo em Inglês | MEDLINE | ID: mdl-29625056

6.

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.

Saphire, Erica Ollmann; Schendel, Sharon L; Fusco, Marnie L; Gangavarapu, Karthik; Gunn, Bronwyn M; Wec, Anna Z; Halfmann, Peter J; Brannan, Jennifer M; Herbert, Andrew S; Qiu, Xiangguo; Wagh, Kshitij; He, Shihua; Giorgi, Elena E; Theiler, James; Pommert, Kathleen B J; Krause, Tyler B; Turner, Hannah L; Murin, Charles D; Pallesen, Jesper; Davidson, Edgar; Ahmed, Rafi; Aman, M Javad; Bukreyev, Alexander; Burton, Dennis R; Crowe, James E; Davis, Carl W; Georgiou, George; Krammer, Florian; Kyratsous, Christos A; Lai, Jonathan R; Nykiforuk, Cory; Pauly, Michael H; Rijal, Pramila; Takada, Ayato; Townsend, Alain R; Volchkov, Viktor; Walker, Laura M; Wang, Cheng-I; Zeitlin, Larry; Doranz, Benjamin J; Ward, Andrew B; Korber, Bette; Kobinger, Gary P; Andersen, Kristian G; Kawaoka, Yoshihiro; Alter, Galit; Chandran, Kartik; Dye, John M.

Cell ; 174(4): 938-952.e13, 2018 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-30096313

7.

Metabolic Phenotypes of Response to Vaccination in Humans.

Li, Shuzhao; Sullivan, Nicole L; Rouphael, Nadine; Yu, Tianwei; Banton, Sophia; Maddur, Mohan S; McCausland, Megan; Chiu, Christopher; Canniff, Jennifer; Dubey, Sheri; Liu, Ken; Tran, ViLinh; Hagan, Thomas; Duraisingham, Sai; Wieland, Andreas; Mehta, Aneesh K; Whitaker, Jennifer A; Subramaniam, Shankar; Jones, Dean P; Sette, Alessandro; Vora, Kalpit; Weinberg, Adriana; Mulligan, Mark J; Nakaya, Helder I; Levin, Myron; Ahmed, Rafi; Pulendran, Bali.

Cell ; 169(5): 862-877.e17, 2017 May 18.

Artigo em Inglês | MEDLINE | ID: mdl-28502771

8.

Reservoir host immune responses to emerging zoonotic viruses.

Mandl, Judith N; Ahmed, Rafi; Barreiro, Luis B; Daszak, Peter; Epstein, Jonathan H; Virgin, Herbert W; Feinberg, Mark B.

Cell ; 160(1-2): 20-35, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25533784

9.

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy.

Wang, Taia T; Maamary, Jad; Tan, Gene S; Bournazos, Stylianos; Davis, Carl W; Krammer, Florian; Schlesinger, Sarah J; Palese, Peter; Ahmed, Rafi; Ravetch, Jeffrey V.

Cell ; 162(1): 160-9, 2015 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-26140596

10.

Translation is actively regulated during the differentiation of CD8⁺ effector T cells.

Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi.

Nat Immunol ; 18(9): 1046-1057, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28714979

11.

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.

Ellebedy, Ali H; Jackson, Katherine J L; Kissick, Haydn T; Nakaya, Helder I; Davis, Carl W; Roskin, Krishna M; McElroy, Anita K; Oshansky, Christine M; Elbein, Rivka; Thomas, Shine; Lyon, George M; Spiropoulou, Christina F; Mehta, Aneesh K; Thomas, Paul G; Boyd, Scott D; Ahmed, Rafi.

Nat Immunol ; 17(10): 1226-34, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-27525369

12.

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection.

Hudson, William H; Gensheimer, Julia; Hashimoto, Masao; Wieland, Andreas; Valanparambil, Rajesh M; Li, Peng; Lin, Jian-Xin; Konieczny, Bogumila T; Im, Se Jin; Freeman, Gordon J; Leonard, Warren J; Kissick, Haydn T; Ahmed, Rafi.

Immunity ; 51(6): 1043-1058.e4, 2019 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-31810882

13.

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8⁺ T cells.

Codarri Deak, Laura; Nicolini, Valeria; Hashimoto, Masao; Karagianni, Maria; Schwalie, Petra C; Lauener, Laura; Varypataki, Eleni Maria; Richard, Marine; Bommer, Esther; Sam, Johannes; Joller, Stefanie; Perro, Mario; Cremasco, Floriana; Kunz, Leo; Yanguez, Emilio; Hüsser, Tamara; Schlenker, Ramona; Mariani, Marisa; Tosevski, Vinko; Herter, Sylvia; Bacac, Marina; Waldhauer, Inja; Colombetti, Sara; Gueripel, Xavier; Wullschleger, Stephan; Tichet, Melanie; Hanahan, Douglas; Kissick, Haydn T; Leclair, Stephane; Freimoser-Grundschober, Anne; Seeber, Stefan; Teichgräber, Volker; Ahmed, Rafi; Klein, Christian; Umaña, Pablo.

Nature ; 610(7930): 161-172, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36171284

14.

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Hashimoto, Masao; Araki, Koichi; Cardenas, Maria A; Li, Peng; Jadhav, Rohit R; Kissick, Haydn T; Hudson, William H; McGuire, Donald J; Obeng, Rebecca C; Wieland, Andreas; Lee, Judong; McManus, Daniel T; Ross, James L; Im, Se Jin; Lee, Junghwa; Lin, Jian-Xin; Hu, Bin; West, Erin E; Scharer, Christopher D; Freeman, Gordon J; Sharpe, Arlene H; Ramalingam, Suresh S; Pellerin, Alex; Teichgräber, Volker; Greenleaf, William J; Klein, Christian; Goronzy, Jorg J; Umaña, Pablo; Leonard, Warren J; Smith, Kendall A; Ahmed, Rafi.

Nature ; 610(7930): 173-181, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36171288

15.

Defining HPV-specific B cell responses in patients with head and neck cancer.

Wieland, Andreas; Patel, Mihir R; Cardenas, Maria A; Eberhardt, Christiane S; Hudson, William H; Obeng, Rebecca C; Griffith, Christopher C; Wang, Xu; Chen, Zhuo G; Kissick, Haydn T; Saba, Nabil F; Ahmed, Rafi.

Nature ; 597(7875): 274-278, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-33208941

16.

Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer.

Eberhardt, Christiane S; Kissick, Haydn T; Patel, Mihir R; Cardenas, Maria A; Prokhnevska, Nataliya; Obeng, Rebecca C; Nasti, Tahseen H; Griffith, Christopher C; Im, Se Jin; Wang, Xu; Shin, Dong M; Carrington, Mary; Chen, Zhuo G; Sidney, John; Sette, Alessandro; Saba, Nabil F; Wieland, Andreas; Ahmed, Rafi.

Nature ; 597(7875): 279-284, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34471285

17.

The Magnitude of IFN-Î³ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.

Petermann, Franziska; Pekowska, Aleksandra; Johnson, Catrina A; Jankovic, Dragana; Shih, Han-Yu; Jiang, Kan; Hudson, William H; Brooks, Stephen R; Sun, Hong-Wei; Villarino, Alejandro V; Yao, Chen; Singleton, Kentner; Akondy, Rama S; Kanno, Yuka; Sher, Alan; Casellas, Rafael; Ahmed, Rafi; O'Shea, John J.

Mol Cell ; 75(6): 1229-1242.e5, 2019 09 19.

Artigo em Inglês | MEDLINE | ID: mdl-31377117

18.

Autophagy is essential for effector CD8(+) T cell survival and memory formation.

Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi.

Nat Immunol ; 15(12): 1152-61, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25362489

19.

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.

Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S; Johnson, Scott E; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M; Quinn, Charlie; Chaussabel, Damien; Palucka, A Karolina; Mulligan, Mark J; Ahmed, Rafi; Stephens, David S; Nakaya, Helder I; Pulendran, Bali.

Nat Immunol ; 15(2): 195-204, 2014 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-24336226

20.

Characteristics and anatomic location of PD-1⁺TCF1⁺ stem-like CD8 T cells in chronic viral infection and cancer.

Im, Se Jin; Obeng, Rebecca C; Nasti, Tahseen H; McManus, Daniel; Kamphorst, Alice O; Gunisetty, Sivaram; Prokhnevska, Nataliya; Carlisle, Jennifer W; Yu, Ke; Sica, Gabriel L; Cardozo, Lucas E; Gonçalves, André N A; Kissick, Haydn T; Nakaya, Helder I; Ramalingam, Suresh S; Ahmed, Rafi.

Proc Natl Acad Sci U S A ; 120(41): e2221985120, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37782797

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