Detalhe da pesquisa
1.
High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity.
J Pharmacol Exp Ther
; 388(1): 209-217, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37918853
2.
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.
Arch Toxicol
; 98(6): 1843-1858, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38551724
3.
Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane.
J Biochem Mol Toxicol
; 37(12): e23505, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598316
4.
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
J Hepatol
; 77(1): 71-83, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35131407
5.
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Arch Toxicol
; 96(2): 453-465, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978586
6.
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Arch Toxicol
; 95(4): 1463-1473, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33458793
7.
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Arch Toxicol
; 95(10): 3377-3391, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34420083
8.
4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
Toxicol Appl Pharmacol
; 409: 115317, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33157119
9.
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.
Toxicol Appl Pharmacol
; 387: 114849, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31809757
10.
Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure.
Biochem Pharmacol
; : 116056, 2024 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346541
11.
Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine.
Toxicology
; 500: 153692, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38042273
12.
Pre- and Post-Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function.
J Endocr Soc
; 7(6): bvad053, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197409
13.
Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
Toxicol Sci
; 197(1): 53-68, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37792503
14.
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Toxicol Lett
; 338: 21-31, 2021 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33290831
15.
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls.
Acta Pharm Sin B
; 11(12): 3740-3755, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024303
16.
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice.
Liver Res
; 5(2): 79-87, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34504721
17.
Fructose Protects Against Acetaminophen-Induced Hepatotoxicity Mainly by Activating the Carbohydrate-Response Element-Binding Protein α-Fibroblast Growth Factor 21 Axis in Mice.
Hepatol Commun
; 5(6): 992-1008, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141985
18.
Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice.
Acta Pharm Sin B
; 11(12): 3791-3805, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024307
19.
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Expert Opin Drug Metab Toxicol
; 16(11): 1039-1050, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32862728
20.
Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure.
Toxicol Sci
; 174(2): 159-167, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31926003