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12.
Gan No Rinsho ; 34(2): 227-32, 1988 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-3346998

RESUMO

A 65-year-old woman visited our hospital, complaining dizziness and abdominal pain. Positive fecal occur blood and an iron-deficiency anemia were found. An investigation of the GI tract was performed, and enteroclysis revealed three stenotic lesions in the ileum, the most distal one having an irregular edge. A superior mesenteric angiogram showed tumor stain and encasement in the ileal region. On laparotomy, a large tumor and multiple stenosis were found in the ileum. Histological examination of the resected specimen confirmed the diagnosis of a carcinoid tumor and healed tuberculosis of the ileum.


Assuntos
Tumor Carcinoide/complicações , Doenças do Íleo/complicações , Neoplasias do Íleo/complicações , Tuberculose Gastrointestinal/complicações , Idoso , Tumor Carcinoide/patologia , Feminino , Humanos , Doenças do Íleo/patologia , Neoplasias do Íleo/patologia , Tuberculose Gastrointestinal/patologia
13.
Jpn J Surg ; 20(4): 369-75, 1990 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-2117682

RESUMO

The ovarian and pituitary functions of 64 operable breast cancer patients undergoing adjuvant therapy with cytotoxic chemotherapy and/or tamoxifen were investigated. The post menopausal patients, divided into 3 treatment groups, one with tamoxifen alone, one with tamoxifen and chemotherapy and the other with chemotherapy alone had serum estradiol 17-beta (E2) and progesterone levels lower than the evaluable limits. Although there was no significant difference in the level of estrone sulfate (E1-S) between these three groups, the level of lutainizing hormone (LH) and follicle stimulating hormone (FSH) in the patients treated with tamoxifen alone and tamoxifen and chemotherapy were significantly lower than those treated with chemotherapy alone. The decrease in gonadotropin levels induced by tamoxifen treatment was reversible as it appeared after the initiation of tamoxifen and recovered after its cessation. In the premenopausal patients, a group treated with tamoxifen and chemotherapy had significantly higher E1-S, E2 and progesterone levels and significantly lower gonadotropin levels than a group treated with chemotherapy alone or one treated with a cyclophosphamide regimen. These increases in the levels of estrogen and progesterone were also reversible, and induced by tamoxifen. Thus, adjuvant endocrinochemotherapy causes profound alteration in the hypothalamo-pituitary-ovarian axis and therefore, monitoring a variety of hormonal levels is thought to be necessary for assessing the consequences of adjuvant therapy in breast cancer patients, especially in premenopausal patients using tamoxifen.


Assuntos
Antibióticos Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Estradiol/sangue , Progesterona/sangue , Tamoxifeno/uso terapêutico , Idoso , Antibióticos Antineoplásicos/administração & dosagem , Neoplasias da Mama/sangue , Neoplasias da Mama/patologia , Ciclofosfamida/administração & dosagem , Ciclofosfamida/efeitos adversos , Ciclofosfamida/uso terapêutico , Avaliação de Medicamentos , Quimioterapia Combinada , Estrona/análogos & derivados , Estrona/sangue , Feminino , Hormônio Foliculoestimulante/sangue , Gonadotropinas/sangue , Humanos , Hormônio Luteinizante/sangue , Pessoa de Meia-Idade , Tamoxifeno/administração & dosagem
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