Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourth-Year PharmD Undergraduates from Riyadh, Saudi Arabia.

BACKGROUND Clinical Trials (CTs) are essential for the formation of a new medicine. This questionnaire-based study included 179 male third- and fourth-year PharmD undergraduate students from Riyadh, Saudi Arabia, between 18 and 23 years of age, was conducted in 2022, and aimed to evaluate student knowledge and attitudes toward CTs. MATERIAL AND METHODS A cross-sectional study was conducted using self-administered questionnaires. The data was collected using convenience sampling. Part 1 of the study collected demographics, with 6 items; part 2 measured knowledge about CTs (9 items); part 3 measured attitudes (5 items) measured on a 5-point Likert scale. A score of 1 was given for correct, and a score of 0 for each incorrect response. Multiple linear regression was used to evaluate the determinants of knowledge and attitudes about CTs. RESULTS A total of 108 (60.3%) undergraduates reported having heard about CTs, 15% of undergraduates had heard about institutional review boards, while 74.3% of the undergraduates believed that CTs have direct benefits to society. The mean knowledge score of the CTs among the students was 5.75±2.32 (median 6.00), while the mean attitude score of CTs was 16.45±4.56 (median 16.00). However, the results of the simple regression model revealed that age, year of study, and chronic disease status were not predictors of the knowledge and attitude score (P>0.05). CONCLUSIONS This study indicated that half of undergraduates were aware of CTs, were knowledgeable, and showed positive attitudes. Furthermore, the study identified potential misunderstandings about the benefits of CTs.

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsia: Insights from a Sudanese Retrospective Study.

BACKGROUND Preeclampsia presents with gestational proteinuria, usually after 20 weeks of gestation, and can be complicated by generalized tonic-clonic seizures of eclampsia. Particularly in countries with limited healthcare resources, preeclampsia and eclampsia are major causes of maternal morbidity and mortality. This retrospective study aimed to evaluate the presentation, management, and outcomes of 185 women with preeclampsia and eclampsia in 2 maternity hospitals in Omdurman, Sudan, between January and December 2020. MATERIAL AND METHODS An analytical retrospective study was conducted in 2 main maternity hospitals in Omdurman, Sudan, between January and December 2020. The study included 185 pregnant women with preeclampsia or eclampsia. Data on clinical and obstetric characteristics (history of the illness, comorbid diseases, parity, gravida, multifetal pregnancy, and laboratory investigations), medications used, and maternal and neonatal outcomes were obtained for the diagnosis. The data were analyzed using the SPSS version 27. RESULTS Results: The mean age was 27.2±6.3 years, with 42.7% primigravida, 30% had a triple-drug regimen, nifedipine was the most common antihypertensive (60.5%), and 17.3% of patients underwent observation only. The seizure rate was 20%, with 92.73% controlled with magnesium sulfate. The antihypertensive regimen before delivery was significantly associated with the mode of delivery (P=0.001) and maternal outcomes (P=0.047); the regimen used after delivery significantly achieved blood pressure control (P=0.043) and improved maternal outcomes (P=0.007), but not fetal outcomes. CONCLUSIONS Maternal outcomes were markedly affected by the antihypertensive drug regimens used and the patient's seizure control status, and use of anti-convulsants successfully controlled all seizures.

Exploring the Educational Social and Physical Activities Among Health Care Undergraduates - a Cross-Sectional Study Among Saudi Students.

BACKGROUND The time spent on diverse social, physical, and educational activities among healthcare undergraduates (HCUs) tremendously impacts their academic and personal lives. Therefore, this study aimed to assess the social, physical, and educational activities among HCUs at King Saud University (KSU) in Riyadh, Saudi Arabia (SA). MATERIAL AND METHODS A cross-sectional, self-prepared, and pre-tested e-questionnaire (electronic questionnaire) based study using a convenience sampling design in a university in SA from August 21 to November 21, 2023 was conducted to assess their various activities outside of classes, using a 16-item e-questionnaire to investigate time spent on social (4 items), physical (3 items), and educational activities (3 items). RESULTS A total of 452 HCUs completed the e-questionnaires, giving a response rate of 92.62%. Of them, 50.45% were females, the median age was 23 years, and 32.08% (n=145) were medical undergraduates. About 57% of the HCUs spent 1-2 h per day on educational activities during the day, while 32.7% of the HCUs spent 2 h per day on social media, and 62.6% spent 3-4 h per day with family. The findings revealed that the 140 females spent significantly more time (1-2 h) reading and writing compared to the 117 male HCUs (P=0.001). Age was found to be associated with time spent on education by HCUs (P=0.001). CONCLUSIONS Our findings among HCUs show that most spend a significant amount of time on educational activities during the day. Undergraduates also spend time with their families and participate in other social activities.

Assessment of Sleeping Disorders, Characteristics, and Sleeping Medication Use Among Pharmacy Students in Saudi Arabia: A Cross-Sectional Quantitative Study.

BACKGROUND Insomnia is a growing problem, especially among university students, and is associated with sleep disorders, poor academic performance, and quality of sleep. The purpose of this study was to assess the prevalence of insomnia sleeping characteristics, managing techniques, and attitudes toward sleeping pill usage among pharmacy students. MATERIAL AND METHODS A cross-sectional web-based study was conducted among pharmacy students of King Saud University, College of Pharmacy, Riyadh, Saudi Arabia between February and March 2023. SPSS version 26 was used for data analysis. A P value of <0.05 and was considered statistically significant. RESULTS In this study, 61.7% (n=108) of the students' slept an average of 6-10 h and 35.4% (n=62) slept an average of 6 h. Regarding sleeping patterns, nearly two-thirds (n=112, 64%) of the students had day and night sleeping patterns while more than one-third (n=63, 36%) had only night sleeping patterns. In this study, 2.9% (n=5) of the students had severe clinical insomnia, while 21.7% (n=38) reported moderately severe clinical insomnia, 44% (n=77) of them had subthreshold insomnia, and 31.4% (n= 55) had no clinically significant insomnia. The mean scores of the insomnia severity index were significantly related to the usage of stimulants (P=0.048), average hours of sleep (P=0.0001), and average minutes needed to fall asleep (P=0.0001). CONCLUSIONS The current findings demonstrated varying levels of insomnia among students, yet few students used sleeping pills.

Navigating Health Literacy and Practices: A Cross-Sectional Study on Nursing Undergraduates in Riyadh, Saudi Arabia.

BACKGROUND This study aimed to assess the health literacy (HL) and health practices (HP) among nursing undergraduates at King Saud University in Riyadh, Saudi Arabia. MATERIAL AND METHODS A cross-sectional survey-based study was conducted in 2023 to assess how nursing students perceive HL and HP. HL is the ability of individuals to acquire, interpret, assess, and act on information to promote and maintain good health, while HP involves the application of knowledge and skills. HL was assessed using a total of 16 items, subdivided into 4 domains (understanding, evaluating, accessing, and utilizing health information) while HP was assessed using 11 items on a 5-point Likert scale. RESULTS In this study, 53.9% of the students were found to have poor HP, while 40.9% (n=166) reported moderate HP, and 5.2% (n=21) reported good HP. With regards to HL, 38.9% (n=158) of students were found to have good HL while 52.2% (n=212) reported moderate HL, and 8.9% (n=36) reported poor HL. The findings indicated that there was a relationship between age and HP, indicating that age is a major predictor of HP (P=0.001). Other comparisons, including year of study, income source, marital status, and the prevalence of chronic conditions, were discovered to have a significant relationship (P=0.001) with HP levels. CONCLUSIONS According to these findings, most students reported poor HP, while one-third claimed good HL. Therefore, there is a need to address the factors related to poor HP while also recommending methods to support good HP among students.

Attitudes towards Exercise, Leisure Activities, and Sedentary Behavior among Adults: A Cross-Sectional, Community-Based Study in Saudi Arabia.

Background: Sedentary behavior has received increased attention as a threat to public health all around the world. A global effort has been made to avoid the spread of noncommunicable diseases (NCDs) that are associated with poor lifestyle practices, which rely on public awareness. As a result, the purpose of this study was to analyze the attitudes toward exercise, leisure activities, and sedentary behaviour among adults in Saudi Arabia. Methods: A cross-sectional study was conducted among individuals living in the Riyadh Region in Saudi Arabia. The questionnaire (26 items) used in this study was divided into four sections, and the first section comprised demographic and basic information of the respondents (6 items). The second section asked the respondents about the time spent exercising and sedentary time spent (6 items), the third section of the study comprised eight questionnaires about the frequency of sedentary activity performed during their leisure time, and the last section was about the attitude towards sedentary behavior (6 items). Descriptive and analytical statistics were done to describe the study findings. Data were analyzed using SPSS version 27. Results: The current findings revealed that 44% (n = 305) of the respondents performed exercise 1-2 days a week, and 16.7% (n = 116) never performed any exercise. Furthermore, a considerable percentage of the respondents spent >4 h in a day as sedentary. Most of the sedentary time was spent on work relating activities 62% (n = 430), followed by time spent on coffee 36.4% (n = 252), business relating activity 22.5% (n = 156), and social media 8.9% (n = 62). In this study, most of the respondents agreed that sitting for a prolonged time might negatively impact their health. Most of the respondents showed positive attitudes towards sedentary behavior. Males were statistically more likely than females to exercise 1-2 days per week (p < 0.001). Being male and being married were both significantly associated with sedentary behavior (p < 0.001). In addition, there was a significant association between participants' sleeping status and physical activity per week, where those who slept 5-6 h often performed physical activity, indicating a significant difference (p < 0.001) than respondents who slept 7-8 or >8 h. The participant's age was also found to have a significant association with engaging in physical exercise (p < 0.001). Conclusions: The results of this study showed that Saudi adults are highly sedentary and inactive, though knowing the harmful consequences of inactivity. Therefore, a national active living policy must be adopted to discourage inactivity and being sedentary and encourage active living in Saudi Arabia.

Evaluation of Headache Trends among Undergraduate First Responders for Medical Emergencies at Saudi University in Riyadh, Saudi Arabia.

Background and objective: Headache is more common among students and may be a crucial indication of mental health; it can have a detrimental impact if left untreated, especially on students, and may affect their academic performance. Thus, this study aimed to assess the headache trends among undergraduate first responders for medical emergencies at Saudi University in Riyadh, Saudi Arabia. Method: A cross-sectional study was undertaken over three months in 2023 to analyze headache patterns among emergency medical services (EMS) students using prevalidated questionnaires. The data were collected via convenience sampling and processed with the IBM SPSS Statistics 26 program (IBM Inc., Chicago, IL, USA). Results: The current findings show that the majority 90.6% (n = 164) of the participants had at least one episode of headache in the last week. With regard to the number of days students had a headache during the last week, 21.5% (n = 39) of them reported 2 days, while 18.8% (n = 34) reported 1 day only. About slightly less than half (48.6% (n = 88)) of students reported that the usual site of the headache was frontal, followed by temporal 27.1% (n = 49), and 23.3% (n = 42) reported orbital. When students were asked whether a headache aggravates their routine activity, 40.3% agreed with this statement, and 44.2% of students reported that a headache causes them to avoid their routine activity (reading writing, attending college). The majority of the students considered taking analgesics (60.8%), followed by sleeping (26.5%), caffeine (14.4%), and herbal and alternative remedies (7.7%) for the relief of headaches. Although headache episodes were significantly associated with routine activities (reading writing, attending college) (p = 0.018, t = 2.282) daily activities (walking, running) (p = 0.022, t = 2.307). The findings showed that fourth-year EMS students were found to have higher headache pain intensity scores compared to other students (p = 0.046). Similarly, the pain intensity was significantly higher among the students between 1-3 and >7 episodes of headaches (p = 0.001) Conclusion: The findings of this study revealed that Saudi emergency medical services students suffer from headaches. However, the current findings revealed variation in the headache pain intensity scores concerning the year of study.

Assessment of Headache Characteristics, Impact, and Managing Techniques among Pharmacy and Nursing Undergraduates-An Observational Study.

Background and Objectives: Many different forms of headaches can change or impact daily activity and quality of life, which increases the financial burden on society over time. Undergraduates who get headaches may be absent from attending lectures, perform less well on their daily tasks and academic achievement, as well as struggle to build and maintain relationships with peers and mentors. Therefore, this study aimed to assess the headache-related characteristics and managing approaches among Saudi pharmacy and nursing students at a Saudi university, in Riyadh, Saudi Arabia. Materials and Methods: A survey questionnaire was administered in this cross-sectional study to participants at a Saudi university, in Riyadh, Saudi Arabia. Participants included males. The sample size was calculated with Raosoft® software. Data analysis was executed using IBM Statistic SPSS, and the level of statistical significance was set at p < 0.05. Results: A total of 236 participants completed the questionnaires. The majority, i.e., 218 (92.4%) of them, were male; in addition, 124 (52.5%) were aged between 26 and 30, 124 (52.5%) were pharmacy students, 112 (47.5%) were nursing students, and 134 (56.8%) were smokers. When asked about ever having at least one episode of headache during the week, 66.1% (n = 156) agreed that they had one episode of headache, although 57 (24.2%) of the students had a headache for five days during a week. With regard to the impact of headaches on everyday activities, only 34.7% of the students said that headache disrupted their regular activities. Almost 41% of the students agreed that headache impacted their academic performance. Nearly 34% of students (n = 79) who had headaches considered napping, while 33% (n = 64) took painkillers and anti-inflammatory medicines, and 25% (n = 59) considered taking caffeine. In this study, the participants' ages and headache severity were strongly associated (p = 0.0001). More pharmacy students (66.1%) reported having severe headaches than nursing students (14.3%) (p = 0.0001). Conclusions: The current findings revealed that most of the undergraduates suffered from headaches, and the intensity of the pain was moderate; furthermore, one in four undergraduates reported that headaches impacted their academic performance. Caffeine and simple analgesics and anti-inflammatories were used for headache relief.

An In Silico Investigation to Explore Anti-Cancer Potential of Foeniculum vulgare Mill. Phytoconstituents for the Management of Human Breast Cancer.

Breast cancer is one of the most prevalent cancers in the world. Traditionally, medicinal plants have been used to cure various types of diseases and disorders. Based on a literature survey, the current study was undertaken to explore the anticancer potential of Foeniculum vulgare Mill. phytoconstituents against breast cancer target protein (PDB ID: 6CHZ) by the molecular docking technique. Molecular docking was done using Autodock/vina software. Toxicity was predicted by the Protox II server and drug likeness was predicted by Molinspiration. 100 ns MD simulation of the best protein-ligand complexes were done using the Amber 18 tool. The present molecular docking investigation has revealed that among the 40 selected phytoconstituents of F. vulgare, α-pinene and D-limonene showed best binding energy (-6 and -5.9 kcal/mol respectively) with the breast cancer target. α-Pinene and D-limonene followed all the parameters of toxicity, and 100 ns MD simulations of α-pinene and D-limonene complexes with 6CHZ were found to be stable. α-Pinene and D-limonene can be used as new therapeutic agents to cure breast cancer.

Community pharmacists awareness, perceptions, and opinions of artificial intelligence: A cross-sectional study in Riyadh, Saudi Arabia.

BACKGROUND: Several revolutions are currently taking place in the healthcare industry to provide accurate, reliable, and valid healthcare to patients. Among these is artificial intelligence (AI). OBJECTIVE: This study aimed to assess the CP's awareness, perceptions, and opinions of AI in health care among community pharmacists. METHODS: This cross-sectional survey-based study was conducted over 3 months in 2023 using structured prevalidated 34 items questionnaires. RESULTS: In this study, 94.5% (n= 258) of the CPs were aware of AI, yet 25.6% (n= 70) believed that AI would eventually replace healthcare professionals. However, 63.4% (n= 173) of the CPs concurred that AI is a technology that supports healthcare workers. 12.8% of the CPs believed that there is a risk of losing their jobs if AI is widely used in Saudi Arabia, but 68.9% (n= 188) of them considered that healthcare professionals will benefit from the extensive use of AI. Eighty-four percent of CPs (n= 232) agreed or strongly agreed that AI decreases drug mistakes in clinical practice. Similarly, 86% of the CPs (n= 235) concurred that AI makes it easier for patients to access the service. In contrast, almost 58% of the CPs (n= 232) agreed that AI makes it easier for healthcare professionals to acquire information, and 87.9% of the CPs (n= 240) said that AI helps them make better decisions. CONCLUSION: This study concluded that most of the CPs were aware of AI and agreed that AI is a tool that helps healthcare professionals. In addition, the majority of the CPs thought that AI adoption in healthcare practice will benefit healthcare practitioners.

Assessment of the Mental, Social, and Educational Impact of the COVID-19 Quarantine and Predictors: A Survey-Based- Study from Saudi Parents.

Background: Quarantine has had a powerful effect on parents and children in Saudi Arabia in different aspects, namely, educational, mental, and social. Therefore, this study aimed to assess the mental, social, and educational impact of the COVID-19 Quarantine and its predictors among Saudi parents. Methods: A cross-sectional study was carried out over 6 months in 2020 using structured questionnaires with 42 items, detailing pre-quarantine assistance with childcare, followed by mental, educational, and social challenges answered using a 5-point Likert scale and the factors affecting their children's learning at home during the COVID-19 quarantine. The data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 27. Results: A response rate of 79.5% (n=831) was obtained. Mental challenges were experienced the most, and 68.1% of the parents worried about their children being infected with COVID-19. This was followed by the educational challenges related to their children's online learning, with 61.2% of the parents attributing it to their children's low motivation towards online learning. The mean score for the education domain was 31.14(±7.02). Similarly, the mean score for the mental impact and social impact was 33.13(±7.82) and 12.81(±2.98). The results of the multiple linear regression analysis revealed participants' gender was found significantly associated with the mean score of the educational domain (p = 0.010). Conclusion: Social challenges were experienced the least, and parents confirmed that quarantine had helped them strengthen their family relations. Most participants agreed that they had fun spending time with both their partners and children. It is recommended to implement online remote activities and services that assist students and professionals in addressing pandemic concerns, such as virtual group exercise, virtual movie nights, and virtual office hours.

The Association between Water, Sanitation, Hygiene, and Child Underweight in Punjab, Pakistan: An Application of Population Attributable Fraction.

Background: Access to safe drinking water, sanitation, and hygiene (WASH) facilities is crucial for health and human rights, impacting nutrition and weight. Methods: Multiple Indicators Cluster Survey (MICS) 2017-18 has been used in this study to examine the association between WASH and underweight, alongside other factors. Analysis included descriptive statistics, association tests, logistic regression, and population-attributable fractions (PAF). Results: According to results child were 1.8, 1.1 and 1.04 times less likely to be underweight if they had access to improved source of drinking water, improved sanitation and hygiene facilities respectively. The likelihood of child being underweight reduces by 1.4, 1.89, 2.01 and 2.55 times if the household wealth status increases from poorest to second, middle, fourth and richest wealth quintiles, respectively. As the mothers' education level increases from no schooling to primary, middle, secondary, and higher level, the possibility of child being underweight reduces by 1.22, 1.24, 1.60 and 2.01 times, respectively. Moreover, the likelihood of a child being underweight decreases as the education level of the household head improves. If maternal age is less than 20 or more than 35 years the likelihood of the child being underweight is increased by 1.074 and 1.121 times, respectively. A child is 1.1 times more likely to be underweight if birth spacing is less than 2 years. A child's risk of being underweight decreases by 1.1 times if they have not experienced diarrhea. A child who has never been breastfed has 1.3 times higher risk of being underweight. The results of Population Attributable Fraction (PAF) indicate that holding the other factors constant, approximately 36.46% burden of underweight was preventable by access to improved drinking water, sanitation, and hygiene practices. Conclusion: Comprehensive strategy is needed that focuses on improving access to safe drinking water, sanitation infrastructure, and hygiene behaviors.

Evaluation of clinical aspects of obesity among undergraduate healthcare students- a cross-sectional study at King Saud University, Riyadh, Kingdom of Saudi Arabia.

BACKGROUND: Obesity among healthcare students (HCs)is a growing concern that needs to be addressed. The purpose of this study was to evaluate the knowledge, awareness, perceptions, practice, and preparedness of obesity, and associated factors among undergraduate HCs. METHODS: A cross-sectional study was conducted from December 2023 to March 2024 using an online prevalidated questionnaire, to assess clinical aspects of obesity.Simple random sampling was applied for data collection from nursing, emergency medical services (EMS), and pharmacy students at Saudi University, Riyadh Saudi Arabia. All data were analyzed using statistical package for social science (SPSS). RESULTS: A total of 456 HCs participated in this study. Among those 68% believed eating high carbohydrates, fats, and sugars leads to obesity. At the same time, 52.2% and 57.2% were aware that smoking and stress can contribute to obesity. On the other hand, 41.9% live a healthy lifestyle and 38.65% engage in physical activity to control their obesity. The demographic variables such as age (p = 0.0001), gender (p = 0.0001), professional classification (p = 0.0001), presence of chronic diseases (p = 0.0001), history of weight loss treatment (p = 0.0001) and body mass index (BMI) (p = 0.0001) were significantly associated with knowledge of obesity(p = 0.001). Similarly, students' age (p = 0.001), presence of chronic diseases (p = 0.004) history of weight loss treatment (p = 0.0001), BMI (p = 0.001), and active status (p = 0.0001) were significantly associated with the perception of the obesity. CONCLUSION: Undergraduate HCs possess a good understanding of the clinical prospects of obesity. They know its causes, risks, and treatment options. Additionally, they are well-prepared to support individuals in managing their weight through lifestyle modifications and psychological counseling.

Evaluation of clinical knowledge of drugs causing addiction and associated social determinants among male pharmacy and nursing students in Riyadh, Saudi Arabia - A Cross-Sectional study.

Drug abuse is a rising psychological concept in many countries, and its use among individuals is increasing. Therefore, this study aimed to assess the Knowledge and demographic factors associated with drug abuse among male pharmacy and nursing students at King Saud University, Riyadh, Saudi Arabia. This study used a cross-sectional design targeting male entry-level pharmacy and nursing students in their first and second years of Bachelor of Nursing and Doctor of Pharmacy courses. Of them, 85.3 % of the pharmacy and 75.3 % of nursing students thought that cocaine causes drug addiction, followed by heroin (pharmacy 80.7 %; nursing students 71 %), and morphine (pharmacy 75.2 %; nursing students 59.1 %). In this study, 52 % (n = 105) claimed low awareness, whereas 48 % (n = 97) indicated good understanding regarding drug addictions. Furthermore, the mean knowledge score among pharmacy students was higher (7.073 ± 2.570) in comparison to nursing (5.806 ± 2.494) (t = 3.540; p = 0. 0001). In addition, the father's occupation was found to be significantly associated with the mean knowledge score of drug addiction (F = 2.667; p = 0.034). According to the findings, 52 % of male students had insufficient knowledge about drugs that cause addiction. Age, course of study, and father's occupation all had a substantial impact on knowledge scores. The knowledge score on the complications of addictive substances was not significantly associated with the characteristics of the students (p = 0.05). As a result, we advocate for the introduction of educational initiatives that educate students about the harmful consequences of drug addiction and how to avoid issues.

Retrospective evaluation of prescribing pattern and utilization of antiepileptic drugs in pediatric, neurosurgery, and psychiatry wards: A comparative study to the standard treatment guidelines.

Antiepileptic drugs (AED) are progressively utilized for off-label conditions other than epilepsy, like bipolar disorder and migraine. The objective of this study was to evaluate current prescribing patterns and utilization of AED in pediatric, neurosurgery, and psychiatry wards and to compare them to the standard treatment guidelines. A descriptive, cross-sectional study was conducted in Ayyub Teaching Hospital, Abbottabad from December 1st, 2018 to April 2019. Data on demographic and clinical characteristics, utilization patterns of AED, adherence to standard treatment guidelines, and frequency of potential drug-drug interactions were analyzed using descriptive statistics. Among 410 patients, 54.3% (n = 223) were male, 45.6%(n = 187) were female, and 63.7% (n = 261) were from the 1 to 18 years' age group. The majority 47.3% (n = 194) were from the pediatric ward followed by neurosurgery 28.7%(n = 118). Among the studied patients, 96.1% of them had comorbid conditions other than epilepsy alone. With regards to types of seizures unclassified seizures were the most common seizure type (59.8%; n = 245) followed by generalized tonic clonic seizures 23.4% (n = 96). In this study, the most frequently utilized AED was sodium valproate 59.0% (n = 242) followed by antiepileptic first-generation medicines were commonly used (76.3%). Although a total of 77.6% of the patients showed nonadherence to National Institute for Health and Care Excellence guidelines and 87.6% of them showed drug interactions. Findings from this study showed prescription patterns and utilization of AED in patients with epilepsy and non-epilepsy disorders which may help healthcare providers in making accurate clinical decisions.

Green synthesis of metal nanoparticles and study their anti-pathogenic properties against pathogens effect on plants and animals.

According to an estimate, 30% to 40%, of global fruit are wasted, leading to post harvest losses and contributing to economic losses ranging from $10 to $100 billion worldwide. Among, all fruits the discarded portion of oranges is around 20%. A novel and value addition approach to utilize the orange peels is in nanoscience. In the present study, a synthesis approach was conducted to prepare the metallic nanoparticles (copper and silver); by utilizing food waste (Citrus plant peels) as bioactive reductants. In addition, the Citrus sinensis extracts showed the reducing activity against metallic salts copper chloride and silver nitrate to form Cu-NPs (copper nanoparticles) and Ag-NPs (Silver nanoparticles). The in vitro potential of both types of prepared nanoparticles was examined against plant pathogenic bacteria Erwinia carotovora (Pectobacterium carotovorum) and pathogens effect on human health Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Moreover, the in vivo antagonistic potential of both types of prepared nanoparticles was examined by their interaction with against plant (potato slices). Furthermore, additional antipathogenic (antiviral and antifungal) properties were also examined. The statistical analysis was done to explain the level of significance and antipathogenic effectiveness among synthesized Ag-NPs and Cu-NPs. The surface morphology, elemental description and size of particles were analyzed by scanning electron microscopy, transmission electron microscopy, energy-dispersive spectroscopy and zeta sizer (in addition polydispersity index and zeta potential). The justification for the preparation of particles was done by UV-Vis Spectroscopy (excitation peaks at 339 nm for copper and 415 nm for silver) and crystalline nature was observed by X-ray diffraction. Hence, the prepared particles are quite effective against soft rot pathogens in plants and can also be used effectively in some other multifunctional applications such as bioactive sport wear, surgical gowns, bioactive bandages and wrist or knee compression bandages, etc.

Questionnaire-Based Study of 392 Women in Abbottabad, Pakistan, to Evaluate the Types of Cosmetic Products Purchased Between December 2018 and March 2019 and Their Associated Adverse Events.

BACKGROUND Cosmetics are applied topically to enhance appearance and are commonly used by women of all ages. Cosmetics contain many chemical agents, but the incidence of adverse reactions is low, possibly due to underreporting. This questionnaire-based study included 392 women to evaluate information on the types of cosmetics purchased between December 2018 and March 2019, their use by the women surveyed, and their associated adverse events. MATERIAL AND METHODS A cross-sectional study was conducted among 392 women in Abbottabad, Pakistan, using a pre-structured and validated questionnaire to evaluate information on the types of cosmetics, their use, and their associated adverse events. Part 1 of the study collected information about demographics. Part 2 contained a total of 11 items, and collected the frequency of use of cosmetic on skin and hair care products. Part 3 consisted of 4 items and collected information about problems encountered due to the use of cosmetics. RESULTS In the winter season, 47.7% (n=187) of women preferred chemical-based cosmetic products, while 30.9% (n=121) preferred Ayurvedic products. Among commonly used cosmetic products, 26.9% (n=106) of women used foundations. The most frequently used skin care product was face wash 39.5% (n=155). The most prevalent adverse events related to cosmetics were pimples (19.9%, n=78), redness (17.6%, n=69), and eye discomfort (15.8%, n=62). Furthermore, 51.3% (n=201) strongly agreed that cosmetics aid in getting a whiter complexion. CONCLUSIONS The survey concluded that most women preferred cosmetics with a chemical base, which are associated with rashes, redness, and acne. It is important to encourage cosmetovigilance and awareness campaigns among cosmetic product sellers and users.

Factors Associated with Sedentary Behavior and Physical Activity Among People Living in Saudi Arabia - A Cross-Sectional Study.

Background: A poor physical activity and sedentary behavior is common among individuals which can be detrimental to one's health. Furthermore, sedentary behavior is associated with metabolic disorders. Therefore, this study explored factors associated with sedentary behavior and physical activity among individuals in capital region of Saudi Arabia. Methods: A cross-sectional web-based study was conducted over a period of 3 months in 2023 using prevalidated questionnaires, which address the sedentary behavior and physical activity and its factors. This study included among individuals aged from 19 to 50 years, living in Riyadh. Factors associated with outcome variables were identified using multiple linear regression analysis in SPSS. Results: Of the 833 study participants, 569 (68.3%) and most were males aged between years 31-35 years old. Only 20.6% (n=172) of the activities that induced high levels of breathing or heart rate were vigorous-intensity activities among the respondents. The average number of sitting hours per day was 6.74 (SD=1.577). The regression model's findings showed a significant correlation between mean sitting time and education level (p=0.008), occupation (p=0.001), monthly income (p=0.029), and kind and status of physical activity (p=0.002). Similar to this, there was a significant correlation between age group (p=0.040) and physical activity status (p=0.001) and the amount of time spent engaging in vigorous-intensity activities at work on an average day. Conclusion: The findings of this study confirmed that Saudi adults living in the Riyadh region spent a significant amount of time sedentary, and the most common factors associated with sedentary behavior were education, employment, monthly income, physical activity status, type of physical activity, and reasons for not practicing physical activity. The findings of this study can be used by healthcare providers and those associated with policymaking to improve health outcomes in healthcare settings.

Evaluation of Young Adults' Physical Activity Status and Perceived Barriers in the Riyadh Region of Saudi Arabia.

Background: Physical activity (PA) is any prolonged movement produced by muscular tissues that cause the muscles to exert force. Despite its beneficial effect, it is frequently neglected by individuals. The present study aimed to determine the PA among young adults living in Saudi Arabia. Methods: This cross-sectional study was conducted among Saudi adults living in the Riyadh region of Saudi Arabia from June to August 2022 through a self-administered online survey. Global Physical Activity Questionnaire was used to assess the PA among participants. The data were analyzed using statistical software SPSS v. 26.0 (SPSS Inc., Chicago, IL, USA). Results: Among the surveyed adult males were the predominant 67.8% (n= 240). Most of them were young, aged between 24 to 34 years 62.4% (n=221), and 37.6% (n=133) of them were between 35 and 44 years old. The current findings reported that 63% (n=223) of the adults had PA on weekly basis. Walking 45.2% (n=160) followed by bodybuilding 12.7% (n=45) was the most common type of PA identified among adults. The barriers identified for not practicing PA were lack of time 46.9% (n=166). With regard to a sedentary lifestyle, it was reported that 9.55 (SD= 4.887) hours per day are spent sedentary or in a constant sitting. The adults gender (p=0.046) employment (p=0.0001) and educational status (p=0.0001) was significantly associated with the type of PA engaged. Although being a female were shown more sitting behavior than males (p<0.047), similarly the nationality of the adults (6.67; SD=1.649) (p <0.001), education (p=0.028) and monthly household income (p =0.024) were significantly associated with the overall mean sitting behavior. Conclusion: The findings of this study confirmed that Saudi adults yet posing highly sedentary behavior and physical inactivity, despite knowing the harmful outcomes of inactivity. Thus educating individuals about the importance of PA is warranted.

A model of purchase intention of complementary and alternative medicines: the role of social media influencers' endorsements.

BACKGROUND: Social Media Influencers (SMIs) are a fashionable way of marketing products by creating electronic word-of-mouth (e-WOM) on social media. The marketing of complementary and alternative medicines (CAMs) by SMIs is becoming increasingly popular and gaining credibility within consumers on social media platforms. Nonetheless, advising about healthcare products on social media should be examined as it is different from endorsing other kinds of commercial products. The aim of this study is to develop a model that provides the underlying mechanisms of the stimuli of SMIs on social media towards consumers' purchase intention of CAMs. METHODS: This study used best fit framework synthesis methods to develop the model. A priori theory selection was conducted by identifying a BeHEMoTh strategy (Behavior of Interest, Health context, Exclusions and Models or Theories) to systematically approach identifying relevant models and theories relative to the research aim. Further evidence derived from primary research studies that describe the behavior identified is coded against selected a priori theory to develop the model. RESULTS: This study presents a novel model for understanding the purchase behavior of CAMs using SMIs as a marketing strategy. The model included two well-known theories (theory of planned behaviour theory and source credibility theory) as well as extensive existing research from a multidisciplinary perspective. The model is exclusively designed to help identify elements affecting perceived source credibility and factors that have an influence over consumers' preferences to purchase CAMs by taking into consideration SMIs' endorsements. CONCLUSIONS: This study provides unique insights introducing new research areas to health literature and offers, new roles for healthcare professionals in this digital era by gaining new skills and competencies required to provide more credible and accurate information about CAMs. The study also highlights the new marketing era of online health-related product endorsements and recommends that policymakers and researchers carefully evaluate the impact of SMI's on the use of CAMs, as well as to regulate the content of these promotional materials.