Detalhe da pesquisa
1.
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib.
Proc Natl Acad Sci U S A
; 121(19): e2315597121, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687786
2.
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals.
Proc Natl Acad Sci U S A
; 116(51): 25745-25755, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31772017
3.
A quantitative, high-throughput reverse genetic screen reveals novel connections between Pre-mRNA splicing and 5' and 3' end transcript determinants.
PLoS Genet
; 8(3): e1002530, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22479188
4.
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors.
Front Pharmacol
; 14: 1328950, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38273820
5.
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.
Front Pharmacol
; 14: 1331224, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38273832
6.
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms.
Nat Commun
; 14(1): 7812, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38097534
7.
RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.
Nat Commun
; 13(1): 2961, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35618715
8.
Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
PLoS Negl Trop Dis
; 16(6): e0010511, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653339
9.
The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming.
Toxins (Basel)
; 13(7)2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34209691
10.
Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
PLoS Negl Trop Dis
; 15(8): e0009659, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34407084
11.
In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms.
Toxins (Basel)
; 12(12)2020 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33287378
12.
Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms.
Acta Pharm Sin B
; 10(10): 1835-1845, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33163338
13.
Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins.
Biomedicines
; 8(9)2020 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32825484
14.
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.
Nat Commun
; 11(1): 6094, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33323937
15.
Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes.
Biomedicines
; 8(6)2020 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560391
16.
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.
Sci Transl Med
; 12(542)2020 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32376771
17.
Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics.
Toxins (Basel)
; 12(1)2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31963329
18.
A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.
Front Pharmacol
; 10: 848, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31417406
19.
The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.
J Proteomics
; 172: 173-189, 2018 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28843532
20.
Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration.
J Mol Biol
; 429(21): 3181-3195, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27771483