Detalhe da pesquisa
1.
Development of orally active inhibitors of protein and cellular fucosylation.
Proc Natl Acad Sci U S A
; 110(14): 5404-9, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23493549
2.
Measurement of in vivo drug load distribution of cysteine-linked antibody-drug conjugates using microscale liquid chromatography mass spectrometry.
Anal Chem
; 86(7): 3420-5, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24576206
3.
Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation.
Bioconjug Chem
; 24(10): 1650-5, 2013 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24050213
4.
Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases.
Clin Cancer Res
; 28(15): 3329-3341, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727144
5.
Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Cancer Chemother Pharmacol
; 89(6): 737-750, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35435471
6.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578993
7.
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas.
Blood
; 113(18): 4352-61, 2009 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19147785
8.
Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.
J Clin Pharmacol
; 61(4): 461-471, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32989831
9.
2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome (Part 1 - Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos).
Bioanalysis
; 13(4): 203-238, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33470871
10.
The pharmacologic basis for antibody-auristatin conjugate activity.
J Pharmacol Exp Ther
; 330(3): 932-8, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19498104
11.
Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index.
Mol Cancer Ther
; 7(9): 2913-23, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790772
12.
Anti-CD30 diabody-drug conjugates with potent antitumor activity.
Mol Cancer Ther
; 7(8): 2486-97, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18723494
13.
2018 White Paper on Recent Issues in Bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (Part 2 - PK, PD & ADA assays by hybrid LBA/LCMS & regulatory agencies' inputs on bioanalysis, biomarkers and immunogenicity).
Bioanalysis
; 10(23): 1897-1917, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30488729
14.
Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97.
Mol Cancer Ther
; 5(6): 1474-82, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16818506
15.
2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).
Bioanalysis
; 9(22): 1807-1825, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148835
16.
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.
Protein Eng Des Sel
; 19(7): 299-307, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16644914
17.
Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
Bioanalysis
; 8(1): 55-63, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647801
18.
2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 2 - hybrid LBA/LCMS and input from regulatory agencies).
Bioanalysis
; 7(23): 3019-34, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627049
19.
Advancing antibody drug conjugation: from the laboratory to a clinically approved anticancer drug.
Hematol Oncol Clin North Am
; 28(1): 13-25, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24287064
20.
2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 3 - LBA and immunogenicity).
Bioanalysis
; 6(24): 3355-68, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534792