Detalhe da pesquisa
1.
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ACS Chem Neurosci
; 14(6): 1080-1094, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812145
2.
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J Med Chem
; 64(9): 6358-6380, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33944571
3.
Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.
PLoS One
; 15(4): e0228771, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255788
4.
Structural Basis for Achieving GSK-3ß Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
J Med Chem
; 62(21): 9600-9617, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31535859