Detalhe da pesquisa
1.
Comparative Evaluation of Dissolution Performance in a USP 2 Setup and Alternative Stirrers and Vessel Designs: A Systematic Computational Investigation.
Mol Pharm
; 21(5): 2406-2414, 2024 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639477
2.
Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer.
Mol Pharm
; 21(1): 201-215, 2024 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38115627
3.
Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs' Performance Issues Related to Gastric pH: Palbociclib Case Study.
Mol Pharm
; 20(1): 147-158, 2023 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36367432
4.
In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.
Mol Pharm
; 18(11): 4122-4130, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34618448
5.
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis.
Mol Pharm
; 18(9): 3326-3341, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34428047
6.
Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies.
Mol Pharm
; 17(7): 2319-2328, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32501703
7.
Hierarchical Mass Transfer Analysis of Drug Particle Dissolution, Highlighting the Hydrodynamics, pH, Particle Size, and Buffer Effects for the Dissolution of Ionizable and Nonionizable Drugs in a Compendial Dissolution Vessel.
Mol Pharm
; 17(10): 3870-3884, 2020 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886520
8.
Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO2-H2CO3 Hydration-Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective p Ka Controlling Dissolution of Acids and Bases.
Mol Pharm
; 16(6): 2626-2635, 2019 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013101
9.
Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance.
Mol Pharm
; 15(11): 5291-5301, 2018 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362350
10.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.
Mol Pharm
; 15(12): 5468-5478, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30417648
11.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.
Mol Pharm
; 15(12): 5454-5467, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30372084
12.
In Vitro Characterization of the Biomimetic Properties of Poly(dimethylsiloxane) To Simulate Oral Drug Absorption.
Mol Pharm
; 14(12): 4661-4674, 2017 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29120190
13.
Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans.
Mol Pharm
; 14(8): 2629-2638, 2017 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28648070
14.
Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization.
Mol Pharm
; 13(3): 1030-46, 2016 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26877267
15.
In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents.
Mol Pharm
; 12(7): 2418-28, 2015 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25985298
16.
Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state.
Mol Pharm
; 11(9): 3039-47, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25115349
17.
Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus.
Biopharm Drug Dispos
; 33(7): 378-402, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22847296
18.
Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen.
J Pharm Sci
; 111(7): 2018-2029, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35120962
19.
Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling.
AAPS J
; 24(1): 17, 2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34982285
20.
The solubility-permeability interplay: mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation.
Mol Pharm
; 8(5): 1848-56, 2011 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21800883