Bibliometric analysis of artificial intelligence in healthcare research: Trends and future directions.

Objective: The presence of artificial intelligence (AI) in healthcare is a powerful and game-changing force that is completely transforming the industry as a whole. Using sophisticated algorithms and data analytics, AI has unparalleled prospects for improving patient care, streamlining operational efficiency, and fostering innovation across the healthcare ecosystem. This study conducts a comprehensive bibliometric analysis of research on AI in healthcare, utilising the SCOPUS database as the primary data source. Methods: Preliminary findings from 2013 identified 153 publications on AI and healthcare. Between 2019 and 2023, the number of publications increased exponentially, indicating significant growth and development in the field. The analysis employs various bibliometric indicators to assess research production performance, science mapping techniques, and thematic mapping analysis. Results: The study reveals insights into research hotspots, thematic focus, and emerging trends in AI and healthcare research. Based on an extensive examination of the Scopus database provides a brief overview and suggests potential avenues for further investigation. Conclusion: This article provides valuable contributions to understanding the current landscape of AI in healthcare, offering insights for future research directions and informing strategic decision making in the field.

E3 ligases: a potential multi-drug target for different types of cancers and neurological disorders.

Ubiquitylation is a posttranslational modification of proteins that is necessary for a variety of cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 ubiquitin ligase are all involved in transferring ubiquitin to the target substrate to regulate cellular function. The objective of this review is to provide an overview of different aspects of E3 ubiquitin ligases that can lead to major biological system failure in several deadly diseases. The first part of this review covers the important characteristics of E3 ubiquitin ligases and their classification based on structural domains. Further, the authors provide some online resources that help researchers explore the data relevant to the enzyme. The following section delves into the involvement of E3 ubiquitin ligases in various diseases and biological processes, including different types of cancer and neurological disorders.

CRISPR/Cas-Based Modifications for Therapeutic Applications: A Review.

The CRISPR-Cas genome editing system is an intrinsic property of a bacteria-based immune system. This employs a guide RNA to detect and cleave the PAM-associated target DNA or RNA in subsequent infections, by the invasion of a similar bacteriophage. The discovery of Cas systems has paved the way to overcome the limitations of existing genome editing tools. In this review, we focus on Cas proteins that are available for gene modifications among which Cas9, Cas12a, and Cas13 have been widely used in the areas of medicine, research, and diagnostics. Since CRISPR has been already proven for its potential research applications, the next milestone for CRISPR will be proving its efficacy and safety. In this connection, we systematically review recent advances in exploring multiple variants of Cas proteins and their modifications for therapeutic applications.