VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths.

The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6-6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting.

Early Childhood Trajectories of Conduct Problems and Callous-Unemotional Traits: The Role of Fearlessness and Psychopathic Personality Dimensions.

Children with early onset of conduct problems (CP) are at risk for long lasting psychosocial problems, especially if CP co-occurs with callous-unemotional (CU) traits. Joint trajectories of CP and CU traits during early childhood were identified using data from the SOFIA study, following 2031 children longitudinally from ages 3-5 to 5-7 years. The results showed that children exhibiting stable high CP and CU traits were characterized by high levels of fearlessness, and psychopathic traits, including grandiose-deceitfulness, and impulsivity, need for stimulation. Children with decreasing or increasing CP and CU traits were characterized by decreases and increases respectively in their levels of fearlessness and psychopathic traits. Children high on CP and low on CU traits exhibited lower levels of these dimensions. Thus, stability and change of fearlessness and psychopathic traits are associated with stability and change in CP and CU traits, making these temperamental and personality traits promising target candidates for early intervention.

Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.

Catechol-O-methyltransferase (COMT) genotype has been implicated as a vulnerability factor for several psychiatric diseases as well as aggressive behavior, either directly, or in interaction with an adverse environment. The present study aimed at investigating the susceptibility properties of COMT genotype to adverse and favorable environment in relation to physical and verbal aggressive behavior. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males). A significant three-way interaction was found, after correction for multiple testing, between COMT genotype, exposure to violence, and parent-child relationship in association with physical but not verbal aggressive behavior. Homozygous for the Val allele reported lower levels of physical aggressive behavior when they were exposed to violence and at the same time experienced a positive parent-child relationship compared to Met carriers. Thus, susceptibility properties of COMT genotype were observed in relation to physical aggressive behavior supporting the hypothesis that COMT genotypes are modifying the sensitivity to environment that confers either risk or protection for aggressive behavior. As these are novel findings, they warrant further investigation and replication in independent samples. © 2016 Wiley Periodicals, Inc.

Types and continua in developmental psychopathology: problem behaviors in school and their relationship to later antisocial behavior.

In the study of developmental psychopathology a dimensional, variable-oriented approach dominates over a typological approach. With the person-oriented research paradigm providing the metatheoretical framework, pros and cons of these two approaches are discussed, and it is pointed to different methodological realizations of the typological approach, and to the contexts where they might be appropriate. It is also pointed out that the two important and underused concepts of equifinality and multifinality with advantage can be incorporated in a person-oriented approach. An empirical example is given of the study of the structure of early adolescent problem behaviors and their relationship to later criminality where dimensional as well as typological analyses are carried out. The usefulness of the typological approach in studying the development and early manifestations of the personality disorder psychopathy is also discussed. It is concluded that the usefulness of a typological approach appears to be underestimated.

Predictors and outcomes of persistent or age-limited registered criminal behavior: a 30-year longitudinal study of a Swedish urban population.

This study uses data from the longitudinal research program Individual Development and Adaptation, where an entire school-grade cohort of children in a middle-size Swedish city (n approximately 1.300) has been followed from ages 10 to 43 and 48 for women and men, respectively. Our findings indicate that the patterns of offending across the life-course differ between genders, where males seem to initiate their offending earlier than females. Further, there are very few women on a persistent offending-trajectory. Focusing on precursors to as well as consequences of offending as indexed in official registers, our results indicate that individuals in the persistent offender group have the most pronounced adjustment problems in school- as well as in middle age. Individual characteristics and behaviors (e.g., aggression, hyperactivity, antisocial behavior) vary systematically between individuals with different developmental offending patterns. The combination of an unstable upbringing and own antisocial behavior seems to be especially predictive for criminality. For persistent offenders, the prevalence of alcohol and psychiatric problems at adult age is high for males and extremely high for females (nine out of ten and six out of ten for each of the two problem types for females). Further, the importance for adjustment of the two-dimensional variation in the number of crimes committed during adolescence and adult age seems to have been surprisingly well captured by the "crude" division into the four offender groups that were used.

Psychopathic Personality Works Better than CU Traits for Predicting Fearlessness and ADHD Symptoms among Children with Conduct Problems.

Children with early-onset conduct problems (CP) are at great risk for future behavior problems, and this risk seems to increase when CP co-occur with psychopathic traits. Even though studies are indicating that the entire psychopathic personality construct may be more useful in designating a meaningful subgroup of children with CP, research on psychopathic traits and CP in childhood have mainly focused on the role of callous unemotional (CU) traits. Prospective longitudinal data of 1867 3- to 5-year-olds (47% girls) followed annually for two years was used to compare groups of children with different combinations of CP and psychopathic traits on fearlessness and Attention-Deficit Hyperactivity Disorder (ADHD) symptoms. Children with CP and psychopathic personality had higher baseline and stable levels of ADHD symptoms than children with CP only or children with CP and concurrent CU traits, while baseline levels of fearlessness did not differ. They were also more likely to display stable levels of the risky combination of CP and ADHD symptoms. Results were similar for boys and girls. Findings indicate that there are reasons to consider other traits and behaviors as specifiers for subgroups of children with CP over and above CU traits, in order to optimize both diagnostic practice and treatment outcomes.

Individual Development and Adaptation (IDA): A Life-Span Longitudinal Program Suited for Person-Oriented Research.

In this article, we give a presentation of the longitudinal research program Individual Development and Adaptation (IDA) that can be helpful as a template for researchers considering to launch their own longitudinal studies, and that opens the door to IDA for researchers looking for suitable data to be analyzed within their own project or in collaboration with IDA. We also introduce the holistic-interactionistic theoretical framework of IDA and the associated person-oriented approach - an approach that is especially suited for analyzing the rich IDA data set with its broad coverage of different areas of adjustment and related factors. The paper provides an overview of the essential features of the IDA database, as well as of ongoing and planned IDA research.

Childhood psychopathic personality and callous-unemotional traits in the prediction of conduct problems.

This study analyzed data from a prospective longitudinal study of Swedish preschoolers to examine whether psychopathic traits and concurrent conduct problems predict future conduct problems (CP) across 1- and 2-year follow-ups into early childhood. We tested the predictive ability of psychopathic traits while controlling for concurrent CP, and also by combining psychopathic traits with concurrent CP. A community sample of 1,867 preschoolers (47% girls) ages 3 to 5 years at baseline was recruited from a Swedish medium-sized municipality. Results from multivariate regression analyses showed that psychopathic traits alone (without co-occurring CP) did not consistently predict continuing childhood CP, but did so, among both boys and girls, in combination with concurrent conduct problems. It is important to note that, the combination of concurrent CP and the entire psychopathic personality, that is, a 3-dimensional psychopathic construct, was a stronger predictor of continuing childhood CP than the combination of concurrent CP and Callous-Unemotional (CU) traits among boys but not among girls. (PsycINFO Database Record

Risk and protective factors among preschool children: integrating research and practice.

In this article the authors present a review of previous reviews and meta-analyses, identifying and summarizing the empirical research base on risk and protective factors for future psychosocial problems-specifically externalizing and internalizing problems-among preschool children. The authors also discuss risk and protective factors in the framework of concepts such as evidence-based practice, risk-focused prevention and treatment, and the Risk, Need, and Responsivity principles. They conclude that there is an extensive amount of research on risk and protective factors for preschool children that could and should be used by well educated professionals to help children to a better life.

Youth victimization in Sweden: prevalence, characteristics and relation to mental health and behavioral problems in young adulthood.

The present study examines multiple types of victimization simultaneously, their prevalence and characteristics in childhood and adolescence, and it examines the associations between victimization and poly-victimization on the one hand and single and multiple mental health and behavioral problems on the other. The sample consisted of 2,500 Swedish young adults (20-24 years) who provided detailed report of multiple types of lifetime victimization and current health and behaviors via an interview and a questionnaire. Results showed that it was more common to be victimized in adolescence than in childhood and more common to be victimized repeatedly rather than a single time, among both males and females. Males and females were victimized in noticeably different ways and partially at different places and by different perpetrators. With regard to mental health and behavioral problems, anxiety, post-traumatic stress, self-harm, and criminality were clearly overrepresented among both males and females who had experienced any type of victimization. Poly-victimization was related to single and multiple mental health and behavioral problems among both males and females. We conclude that professionals need to conduct thorough evaluations of victimization when completing mental health assessments among troubled youths, and that youth might benefit from the development of interventions for poly-victimized youth.

A New Measure to Assess Psychopathic Personality in Children: The Child Problematic Traits Inventory.

Understanding the development of psychopathic personality from childhood to adulthood is crucial for understanding the development and stability of severe and long-lasting conduct problems and criminal behavior. This paper describes the development of a new teacher rated instrument to assess psychopathic personality from age three to 12, the Child Problematic Traits Inventory (CPTI). The reliability and validity of the CPTI was tested in a Swedish general population sample of 2,056 3- to 5-year-olds (mean age = 3.86; SD = .86; 53 % boys). The CPTI items loaded distinctively on three theoretically proposed factors: a Grandiose-Deceitful Factor, a Callous-Unemotional factor, and an Impulsive-Need for Stimulation factor. The three CPTI factors showed reliability in internal consistency and external validity, in terms of expected correlations with theoretically relevant constructs (e.g., fearlessness). The interaction between the three CPTI factors was a stronger predictor of concurrent conduct problems than any of the three individual CPTI factors, showing that it is important to assess all three factors of the psychopathic personality construct in early childhood. In conclusion, the CPTI seems to reliably and validly assess a constellation of traits that is similar to psychopathic personality as manifested in adolescence and adulthood.

Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation.

Genetic factors are important for the association between parental negativity and child problem behavior, but it is not clear whether this is due to passive or evocative genotype-environment correlation (rGE). In this study, we applied the extended children-of-twins model to directly examine the presence of passive and evocative rGE as well as direct environmental effects in the association between parental criticism and adolescent externalizing problem behavior. The cross-sectional data come from the Twin and Offspring Study in Sweden (N = 909 pairs of adult twins) and from the Twin Study of Child and Adolescent Development (N = 915 pairs of twin children). The results revealed that maternal criticism was primarily due to evocative rGE emanating from their adolescent's externalizing behavior. On the other hand, fathers' critical remarks tended to affect adolescent problem behavior in a direct environmental way. This suggests that previously reported differences in caretaking between mothers and fathers also are reflected in differences in why parenting is associated with externalizing behavior in offspring.

Aggression as a mediator of genetic contributions to the association between negative parent-child relationships and adolescent antisocial behavior.

Previous research suggests that the association between conflictual parent-child relationships and maladjustment among adolescents is influenced by genetic effects emanating from the adolescents. In this study, we examined whether these effects are mediated by childhood aggression. The data come from the Twin study of CHild and Adolescent Development (TCHAD), a Swedish longitudinal study including 1,314 twin pairs followed from age 13-14 to 16-17. Early adolescent aggression, parental criticism, and delinquency in later adolescence were rated by parents and children at different time points. Multivariate genetic structural equation models were used to estimate genetic and environmental influences on these constructs and on their covariation. The results showed that approximately half of the genetic contribution to the association between parental criticism and delinquency was explained by early adolescent aggression. It suggests that aggression in children evokes negative parenting, which in turn influences adolescent antisocial behavior. The mechanism proposed by these findings is consistent with evocative gene-environment correlation.