Detalhe da pesquisa
1.
Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.
Pharmacol Res
; 111: 208-216, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27317944
2.
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists.
Bioorg Med Chem Lett
; 24(21): 5111-7, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437503
3.
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I.
Bioorg Med Chem Lett
; 24(21): 5118-22, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437504
4.
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization.
Bioorg Med Chem Lett
; 24(21): 5123-6, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437505
5.
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: the role of a hydrogen-bond acceptor in long receptor residence times.
Bioorg Med Chem Lett
; 24(21): 5127-33, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437506
6.
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.
Bioorg Med Chem Lett
; 23(11): 3349-53, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601708
7.
Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Bioorg Med Chem Lett
; 21(24): 7268-72, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22078215
8.
4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships.
J Med Chem
; 61(6): 2472-2489, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29502405
9.
Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
PLoS One
; 13(1): e0189247, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29320511
10.
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
J Med Chem
; 59(23): 10479-10497, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933955
11.
Pharmacological characterization of F-180: a selective human V(1a) vasopressin receptor agonist of high affinity.
Br J Pharmacol
; 135(7): 1828-36, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11934825
12.
Comparative pharmacology of bovine, human and rat vasopressin receptor isoforms.
Eur J Pharmacol
; 501(1-3): 59-69, 2004 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15464063
13.
2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists.
Eur J Med Chem
; 71: 168-84, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24292338
14.
V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH.
Mol Endocrinol
; 26(3): 502-20, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22301784
15.
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Eur J Med Chem
; 46(10): 4946-56, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21871695
16.
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
J Med Chem
; 53(19): 6912-22, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20825218
17.
Light-dependant biostabilisation of sediments by stromatolite assemblages.
PLoS One
; 3(9): e3176, 2008 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18781202