RESUMO
Malignant mesothelioma is an uncommon neoplasm that develops from serous surfaces, and rarely from the tunica vaginalis. Although atypical in any location, paratesticular presentation is exceedingly infrequent as only 0.3% to 1.4% of mesothelioma cases arise from the tunica vaginalis. Fewer than 300 cases have been reported with very few descriptions of long term follow up and multimodal therapy. Here we describe a patient with 2 years of follow up for metastatic mesothelioma treated with orchiectomy, chemotherapy and robot-assisted laparoscopic retroperitoneal lymph node dissection.
Assuntos
Túnica Adventícia/patologia , Antineoplásicos/administração & dosagem , Neoplasias Pulmonares , Excisão de Linfonodo/métodos , Mesotelioma , Orquiectomia/métodos , Procedimentos Cirúrgicos Robóticos/métodos , Hidrocele Testicular , Neoplasias Testiculares , Biópsia/métodos , Terapia Combinada/métodos , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Metástase Linfática , Masculino , Mesotelioma/complicações , Mesotelioma/diagnóstico , Mesotelioma/patologia , Mesotelioma/cirurgia , Mesotelioma Maligno , Pessoa de Meia-Idade , Espaço Retroperitoneal , Hidrocele Testicular/diagnóstico , Hidrocele Testicular/etiologia , Hidrocele Testicular/cirurgia , Neoplasias Testiculares/complicações , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/patologia , Neoplasias Testiculares/cirurgia , Resultado do TratamentoRESUMO
An 11-year-old female with spastic quadriplegia was seen in the emergency room with abdominal pain, vomiting and anorexia. Labs revealed possible pancreatitis and signs of a urinary tract infection. A CT scan was performed to assess her abdominal pain and demonstrated circumferential air within the bladder wall. Following cultures being drawn, she was started on broad spectrum antibiotics. Her urine eventually grew Klebsiella Pneumoniae. Follow up imaging 2 weeks later demonstrated resolution of the air. Emphysematous cystitis is an exceedingly rare condition in the pediatric population, with this report representing the second case within the literature.
Assuntos
Cistite/microbiologia , Enfisema/microbiologia , Infecções por Klebsiella/complicações , Infecções Urinárias/complicações , Antibacterianos/uso terapêutico , Paralisia Cerebral/complicações , Criança , Cistite/diagnóstico por imagem , Enfisema/diagnóstico por imagem , Feminino , Humanos , Infecções por Klebsiella/tratamento farmacológico , Klebsiella pneumoniae , Quadriplegia/complicações , Doenças Raras/diagnóstico por imagem , Doenças Raras/microbiologia , Tomografia Computadorizada por Raios X , Infecções Urinárias/tratamento farmacológicoRESUMO
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as a new scaffold for the development of allosteric inhibitors of liver pyruvate kinase (PKL). In this work, a comprehensive structure-activity analysis of urolithin C was carried out. More than 50 analogues were synthesized and tested regarding the chemical features responsible for the desired activity. These data could pave the way to the development of more potent and selective PKL allosteric inhibitors.