1.
ACS Synth Biol
; 6(11): 2021-2027, 2017 11 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28945972
RESUMO
We developed an ultrasound-chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.
Assuntos
Microbolhas , Multimerização Proteica , Ondas Ultrassônicas , Animais , Células COS , Chlorocebus aethiops , Células HeLa , Humanos
2.
J Antibiot (Tokyo)
; 67(1): 133-6, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24169799