Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial.

Hamer, Melinda J; Houser, Katherine V; Hofstetter, Amelia R; Ortega-Villa, Ana M; Lee, Christine; Preston, Anne; Augustine, Brooke; Andrews, Charla; Yamshchikov, Galina V; Hickman, Somia; Schech, Steven; Hutter, Jack N; Scott, Paul T; Waterman, Paige E; Amare, Mihret F; Kioko, Victoria; Storme, Casey; Modjarrad, Kayvon; McCauley, Melanie D; Robb, Merlin L; Gaudinski, Martin R; Gordon, Ingelise J; Holman, LaSonji A; Widge, Alicia T; Strom, Larisa; Happe, Myra; Cox, Josephine H; Vazquez, Sandra; Stanley, Daphne A; Murray, Tamar; Dulan, Caitlyn N M; Hunegnaw, Ruth; Narpala, Sandeep R; Swanson, Phillip A; Basappa, Manjula; Thillainathan, Jagada; Padilla, Marcelino; Flach, Britta; O'Connell, Sarah; Trofymenko, Olga; Morgan, Patricia; Coates, Emily E; Gall, Jason G; McDermott, Adrian B; Koup, Richard A; Mascola, John R; Ploquin, Aurélie; Sullivan, Nancy J; Ake, Julie A; Ledgerwood, Julie E.

Lancet ; 401(10373): 294-302, 2023 01 28.

Artigo em Inglês | MEDLINE | ID: mdl-36709074

2.

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study.

Gaudinski, Martin R; Coates, Emily E; Novik, Laura; Widge, Alicia; Houser, Katherine V; Burch, Eugeania; Holman, LaSonji A; Gordon, Ingelise J; Chen, Grace L; Carter, Cristina; Nason, Martha; Sitar, Sandra; Yamshchikov, Galina; Berkowitz, Nina; Andrews, Charla; Vazquez, Sandra; Laurencot, Carolyn; Misasi, John; Arnold, Frank; Carlton, Kevin; Lawlor, Heather; Gall, Jason; Bailer, Robert T; McDermott, Adrian; Capparelli, Edmund; Koup, Richard A; Mascola, John R; Graham, Barney S; Sullivan, Nancy J; Ledgerwood, Julie E.

Lancet ; 393(10174): 889-898, 2019 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-30686586

3.

Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial.

Chen, Grace L; Coates, Emily E; Plummer, Sarah H; Carter, Cristina A; Berkowitz, Nina; Conan-Cibotti, Michelle; Cox, Josephine H; Beck, Allison; O'Callahan, Mark; Andrews, Charla; Gordon, Ingelise J; Larkin, Brenda; Lampley, Rebecca; Kaltovich, Florence; Gall, Jason; Carlton, Kevin; Mendy, Jason; Haney, Doug; May, Jeanine; Bray, Amy; Bailer, Robert T; Dowd, Kimberly A; Brockett, Brittanie; Gordon, David; Koup, Richard A; Schwartz, Richard; Mascola, John R; Graham, Barney S; Pierson, Theodore C; Donastorg, Yeycy; Rosario, Nicolas; Pape, Jean William; Hoen, Bruno; Cabié, André; Diaz, Clemente; Ledgerwood, Julie E.

JAMA ; 323(14): 1369-1377, 2020 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-32286643

4.

Immune-correlates analysis of an HIV-1 vaccine efficacy trial.

Haynes, Barton F; Gilbert, Peter B; McElrath, M Juliana; Zolla-Pazner, Susan; Tomaras, Georgia D; Alam, S Munir; Evans, David T; Montefiori, David C; Karnasuta, Chitraporn; Sutthent, Ruengpueng; Liao, Hua-Xin; DeVico, Anthony L; Lewis, George K; Williams, Constance; Pinter, Abraham; Fong, Youyi; Janes, Holly; DeCamp, Allan; Huang, Yunda; Rao, Mangala; Billings, Erik; Karasavvas, Nicos; Robb, Merlin L; Ngauy, Viseth; de Souza, Mark S; Paris, Robert; Ferrari, Guido; Bailer, Robert T; Soderberg, Kelly A; Andrews, Charla; Berman, Phillip W; Frahm, Nicole; De Rosa, Stephen C; Alpert, Michael D; Yates, Nicole L; Shen, Xiaoying; Koup, Richard A; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Rerks-Ngarm, Supachai; Michael, Nelson L; Kim, Jerome H.

N Engl J Med ; 366(14): 1275-86, 2012 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-22475592

5.

HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV vaccine clinical trial.

Prentice, Heather A; Ehrenberg, Philip K; Baldwin, Karen M; Geretz, Aviva; Andrews, Charla; Nitayaphan, Sorachai; Rerks-Ngarm, Supachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; O'Connell, Robert J; Robb, Merlin L; Kim, Jerome H; Michael, Nelson L; Thomas, Rasmi.

Immunogenetics ; 66(5): 299-310, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24682434

6.

Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire.

Casazza, Joseph P; Bowman, Kathryn A; Adzaku, Selorm; Smith, Emily C; Enama, Mary E; Bailer, Robert T; Price, David A; Gostick, Emma; Gordon, Ingelise J; Ambrozak, David R; Nason, Martha C; Roederer, Mario; Andrews, Charla A; Maldarelli, Frank M; Wiegand, Ann; Kearney, Mary F; Persaud, Deborah; Ziemniak, Carrie; Gottardo, Raphael; Ledgerwood, Julie E; Graham, Barney S; Koup, Richard A.

J Infect Dis ; 207(12): 1829-40, 2013 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-23482645

7.

Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E.

Rerks-Ngarm, Supachai; Paris, Robert M; Chunsutthiwat, Supamit; Premsri, Nakorn; Namwat, Chawetsan; Bowonwatanuwong, Chureeratana; Li, Shuying S; Kaewkungkal, Jaranit; Trichavaroj, Rapee; Churikanont, Nampueng; de Souza, Mark S; Andrews, Charla; Francis, Donald; Adams, Elizabeth; Flores, Jorge; Gurunathan, Sanjay; Tartaglia, Jim; O'Connell, Robert J; Eamsila, Chirapa; Nitayaphan, Sorachai; Ngauy, Viseth; Thongcharoen, Prasert; Kunasol, Prayura; Michael, Nelson L; Robb, Merlin L; Gilbert, Peter B; Kim, Jerome H.

J Infect Dis ; 207(8): 1195-205, 2013 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-22837492

8.

Genetic immunization in the lung induces potent local and systemic immune responses.

Song, Kaimei; Bolton, Diane L; Wei, Chih-Jen; Wilson, Robert L; Camp, Jeremy V; Bao, Saran; Mattapallil, Joseph J; Herzenberg, Leonore A; Herzenberg, Leonard A; Andrews, Charla A; Sadoff, Jerald C; Goudsmit, Jaap; Pau, Maria Grazia; Seder, Robert A; Kozlowski, Pamela A; Nabel, Gary J; Roederer, Mario; Rao, Srinivas S.

Proc Natl Acad Sci U S A ; 107(51): 22213-8, 2010 Dec 21.

Artigo em Inglês | MEDLINE | ID: mdl-21135247

9.

Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials.

Montefiori, David C; Karnasuta, Chitraporn; Huang, Ying; Ahmed, Hasan; Gilbert, Peter; de Souza, Mark S; McLinden, Robert; Tovanabutra, Sodsai; Laurence-Chenine, Agnes; Sanders-Buell, Eric; Moody, M Anthony; Bonsignori, Mattia; Ochsenbauer, Christina; Kappes, John; Tang, Haili; Greene, Kelli; Gao, Hongmei; LaBranche, Celia C; Andrews, Charla; Polonis, Victoria R; Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Self, Steve G; Berman, Phillip W; Francis, Donald; Sinangil, Faruk; Lee, Carter; Tartaglia, Jim; Robb, Merlin L; Haynes, Barton F; Michael, Nelson L; Kim, Jerome H.

J Infect Dis ; 206(3): 431-41, 2012 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-22634875

10.

Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial.

Mwesigwa, Betty; Houser, Katherine V; Hofstetter, Amelia R; Ortega-Villa, Ana M; Naluyima, Prossy; Kiweewa, Francis; Nakabuye, Immaculate; Yamshchikov, Galina V; Andrews, Charla; O'Callahan, Mark; Strom, Larisa; Schech, Steven; Anne Eller, Leigh; Sondergaard, Erica L; Scott, Paul T; Amare, Mihret F; Modjarrad, Kayvon; Wamala, Amir; Tindikahwa, Allan; Musingye, Ezra; Nanyondo, Jauhara; Gaudinski, Martin R; Gordon, Ingelise J; Holman, LaSonji A; Saunders, Jamie G; Costner, Pamela J M; Mendoza, Floreliz H; Happe, Myra; Morgan, Patricia; Plummer, Sarah H; Hickman, Somia P; Vazquez, Sandra; Murray, Tamar; Cordon, Jamilet; Dulan, Caitlyn N M; Hunegnaw, Ruth; Basappa, Manjula; Padilla, Marcelino; Gajjala, Suprabhath R; Swanson, Phillip A; Lin, Bob C; Coates, Emily E; Gall, Jason G; McDermott, Adrian B; Koup, Richard A; Mascola, John R; Ploquin, Aurélie; Sullivan, Nancy J; Kibuuka, Hannah; Ake, Julie A.

Lancet Infect Dis ; 23(12): 1408-1417, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37544326

11.

Safety and immunogenicity of a trivalent virus-like particle vaccine against western, eastern, and Venezuelan equine encephalitis viruses: a phase 1, open-label, dose-escalation, randomised clinical trial.

Coates, Emily E; Edupuganti, Srilatha; Chen, Grace L; Happe, Myra; Strom, Larisa; Widge, Alicia; Florez, Maria Burgos; Cox, Josephine H; Gordon, Ingelise; Plummer, Sarah; Ola, Abidemi; Yamshchikov, Galina; Andrews, Charla; Curate-Ingram, Sharon; Morgan, Patricia; Nagar, Shashi; Collins, Matthew H; Bray, Amy; Nguyen, Thuy; Stein, Judy; Case, Christopher L; Kaltovich, Florence; Wycuff, Diane; Liang, C Jason; Carlton, Kevin; Vazquez, Sandra; Mascola, John R; Ledgerwood, Julie E.

Lancet Infect Dis ; 22(8): 1210-1220, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35568049

12.

Ethical and scientific implications of the globalization of clinical research.

Andrews, Charla A.

N Engl J Med ; 360(26): 2793; author reply 2793, 2009 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-19557890

13.

Toxicological safety evaluation of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar despite differing plasmid backbones or gene-inserts.

Sheets, Rebecca L; Stein, Judith; Manetz, T Scott; Andrews, Charla; Bailer, Robert; Rathmann, John; Gomez, Phillip L.

Toxicol Sci ; 91(2): 620-30, 2006 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-16569728

14.

Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts.

Sheets, Rebecca L; Stein, Judith; Manetz, T Scott; Duffy, Chris; Nason, Martha; Andrews, Charla; Kong, Wing-Pui; Nabel, Gary J; Gomez, Phillip L.

Toxicol Sci ; 91(2): 610-9, 2006 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-16569729

15.

IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens.

Karasavvas, Nicos; Karnasuta, Chitraporn; Savadsuk, Hathairat; Madnote, Sirinan; Inthawong, Dutsadee; Chantakulkij, Somsak; Rittiroongrad, Surawach; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Thongcharoen, Prasert; Siriyanon, Vinai; Andrews, Charla A; Barnett, Susan W; Tartaglia, James; Sinangil, Faruk; Francis, Donald P; Robb, Merlin L; Michael, Nelson L; Ngauy, Viseth; de Souza, Mark S; Paris, Robert M; Excler, Jean-Louis; Kim, Jerome H; O'Connell, Robert J.

AIDS Res Hum Retroviruses ; 31(11): 1178-86, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26234467

16.

Comparison of symptoms of influenza A with abacavir-associated hypersensitivity reaction.

Keiser, Philip; Nassar, Naiel; Skiest, Daniel; Andrews, Charla; Yazdani, Beena; White, Alice; Hetherington, Seth.

Int J STD AIDS ; 14(7): 478-81, 2003 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-12869229

17.

Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines.

Chung, Amy W; Ghebremichael, Musie; Robinson, Hannah; Brown, Eric; Choi, Ickwon; Lane, Sophie; Dugast, Anne-Sophie; Schoen, Matthew K; Rolland, Morgane; Suscovich, Todd J; Mahan, Alison E; Liao, Larry; Streeck, Hendrik; Andrews, Charla; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; de Souza, Mark S; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Francis, Donald; Michael, Nelson L; Kim, Jerome H; Bailey-Kellogg, Chris; Ackerman, Margaret E; Alter, Galit.

Sci Transl Med ; 6(228): 228ra38, 2014 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-24648341

18.

Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection.

Zolla-Pazner, Susan; deCamp, Allan; Gilbert, Peter B; Williams, Constance; Yates, Nicole L; Williams, William T; Howington, Robert; Fong, Youyi; Morris, Daryl E; Soderberg, Kelly A; Irene, Carmela; Reichman, Charles; Pinter, Abraham; Parks, Robert; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Andrews, Charla; O'Connell, Robert J; Yang, Zhi-yong; Nabel, Gary J; Kim, Jerome H; Michael, Nelson L; Montefiori, David C; Liao, Hua-Xin; Haynes, Barton F; Tomaras, Georgia D.

PLoS One ; 9(2): e87572, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24504509

19.

Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial.

Zolla-Pazner, Susan; deCamp, Allan C; Cardozo, Timothy; Karasavvas, Nicos; Gottardo, Raphael; Williams, Constance; Morris, Daryl E; Tomaras, Georgia; Rao, Mangala; Billings, Erik; Berman, Phillip; Shen, Xiaoying; Andrews, Charla; O'Connell, Robert J; Ngauy, Viseth; Nitayaphan, Sorachai; de Souza, Mark; Korber, Bette; Koup, Richard; Bailer, Robert T; Mascola, John R; Pinter, Abraham; Montefiori, David; Haynes, Barton F; Robb, Merlin L; Rerks-Ngarm, Supachai; Michael, Nelson L; Gilbert, Peter B; Kim, Jerome H.

PLoS One ; 8(1): e53629, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23349725

20.

The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120.

Karasavvas, Nicos; Billings, Erik; Rao, Mangala; Williams, Constance; Zolla-Pazner, Susan; Bailer, Robert T; Koup, Richard A; Madnote, Sirinan; Arworn, Duangnapa; Shen, Xiaoying; Tomaras, Georgia D; Currier, Jeffrey R; Jiang, Mike; Magaret, Craig; Andrews, Charla; Gottardo, Raphael; Gilbert, Peter; Cardozo, Timothy J; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Paris, Robert; Greene, Kelli; Gao, Hongmei; Gurunathan, Sanjay; Tartaglia, Jim; Sinangil, Faruk; Korber, Bette T; Montefiori, David C; Mascola, John R; Robb, Merlin L; Haynes, Barton F; Ngauy, Viseth; Michael, Nelson L; Kim, Jerome H; de Souza, Mark S.

AIDS Res Hum Retroviruses ; 28(11): 1444-57, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23035746

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