Detalhe da pesquisa
1.
Design and synthesis of potent RSK inhibitors.
Bioorg Med Chem Lett
; 28(19): 3197-3201, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30170943
2.
Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Bioorg Med Chem Lett
; 27(23): 5221-5224, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107542
3.
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.
Bioorg Med Chem Lett
; 24(6): 1592-6, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24534486
4.
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
EMBO J
; 26(23): 4902-12, 2007 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17989695
5.
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Nat Chem Biol
; 5(4): 217-9, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19252499
6.
A specificity map for the PDZ domain family.
PLoS Biol
; 6(9): e239, 2008 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18828675
7.
GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv
; 7(40): eabj2485, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34597140
8.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J Med Chem
; 63(5): 2013-2027, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31059256
9.
The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes.
Structure
; 14(1): 87-96, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16407068
10.
Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.
J Med Chem
; 61(8): 3325-3349, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29551072
11.
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J Med Chem
; 61(8): 3309-3324, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29498517
12.
Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain.
Protein Sci
; 16(8): 1738-50, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17656586
13.
Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3.
Protein Sci
; 16(11): 2454-71, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17962403
14.
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J Med Chem
; 60(12): 4869-4881, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28557458
15.
Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J Med Chem
; 58(17): 6766-83, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26270416
16.
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
ACS Med Chem Lett
; 6(9): 961-5, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396681
17.
A structural portrait of the PDZ domain family.
J Mol Biol
; 426(21): 3509-19, 2014 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25158098
18.
Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.
Mol Cancer Res
; 12(5): 803-12, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24554780
19.
A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.
Cancer Res
; 71(15): 5255-64, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697284
20.
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.
Structure
; 17(10): 1398-410, 2009 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19836339