Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Dejean, Anne S; Beisner, Daniel R; Ch'en, Irene L; Kerdiles, Yann M; Babour, Anna; Arden, Karen C; Castrillon, Diego H; DePinho, Ronald A; Hedrick, Stephen M.

Nat Immunol ; 10(5): 504-13, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19363483

2.

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

Dengler, Hart S; Baracho, Gisele V; Omori, Sidne A; Bruckner, Shane; Arden, Karen C; Castrillon, Diego H; DePinho, Ronald A; Rickert, Robert C.

Nat Immunol ; 9(12): 1388-98, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18978794

3.

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass.

Hashimoto, Naoko; Kido, Yoshiaki; Uchida, Tohru; Asahara, Shun-ichiro; Shigeyama, Yutaka; Matsuda, Tomokazu; Takeda, Akihiko; Tsuchihashi, Daisuke; Nishizawa, Akihiko; Ogawa, Wataru; Fujimoto, Yoshito; Okamura, Hitoshi; Arden, Karen C; Herrera, Pedro L; Noda, Tetsuo; Kasuga, Masato.

Nat Genet ; 38(5): 589-93, 2006 May.

Artigo em Inglês | MEDLINE | ID: mdl-16642023

4.

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

Nakae, Jun; Biggs, William H; Kitamura, Tadahiro; Cavenee, Webster K; Wright, Christopher V E; Arden, Karen C; Accili, Domenico.

Nat Genet ; 32(2): 245-53, 2002 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-12219087

5.

PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.

Roeb, Wendy; Boyer, Antonia; Cavenee, Webster K; Arden, Karen C.

Proc Natl Acad Sci U S A ; 104(46): 18085-90, 2007 Nov 13.

Artigo em Inglês | MEDLINE | ID: mdl-17986608

6.

The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

Nakae, Jun; Kitamura, Tadahiro; Kitamura, Yukari; Biggs, William H; Arden, Karen C; Accili, Domenico.

Dev Cell ; 4(1): 119-29, 2003 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-12530968

7.

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura, Tadahiro; Nakae, Jun; Kitamura, Yukari; Kido, Yoshiaki; Biggs, William H; Wright, Christopher V E; White, Morris F; Arden, Karen C; Accili, Domenico.

J Clin Invest ; 110(12): 1839-47, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-12488434

8.

Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer.

Arden, Karen C.

Exp Gerontol ; 41(8): 709-17, 2006 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-16806782

9.

Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling.

Harding, Michael A; Arden, Karen C; Gildea, James W; Gildea, John J; Perlman, Elizabeth J; Viars, Carrie; Theodorescu, Dan.

Cancer Res ; 62(23): 6981-9, 2002 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-12460916

10.

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.

Kim, Jane J; Li, Pingping; Huntley, Jessica; Chang, Jeffrey P; Arden, Karen C; Olefsky, Jerrold M.

Diabetes ; 58(6): 1275-82, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19289458

11.

Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor.

Roeb, Wendy; Boyer, Antonia; Cavenee, Webster K; Arden, Karen C.

Cell Cycle ; 7(7): 837-41, 2008 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-18414034

12.

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.

Barrera, Leah O; Li, Zirong; Smith, Andrew D; Arden, Karen C; Cavenee, Webster K; Zhang, Michael Q; Green, Roland D; Ren, Bing.

Genome Res ; 18(1): 46-59, 2008 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-18042645

13.

FoxOs in tumor suppression and stem cell maintenance.

Arden, Karen C.

Cell ; 128(2): 235-7, 2007 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-17254960

14.

Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube.

Finckenstein, Friedrich Graf; Davicioni, Elai; Osborn, Kent G; Cavenee, Webster K; Arden, Karen C; Anderson, Michael J.

Transgenic Res ; 15(5): 595-614, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16952014

15.

FoxO: linking new signaling pathways.

Arden, Karen C.

Mol Cell ; 14(4): 416-8, 2004 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-15149589

16.

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

Accili, Domenico; Arden, Karen C.

Cell ; 117(4): 421-6, 2004 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-15137936

17.

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.

Hosaka, Taisuke; Biggs, William H; Tieu, David; Boyer, Antonia D; Varki, Nissi M; Cavenee, Webster K; Arden, Karen C.

Proc Natl Acad Sci U S A ; 101(9): 2975-80, 2004 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-14978268

18.

Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.

Johnstone, Cameron N; White, Sara J; Tebbutt, Niall C; Clay, Fiona J; Ernst, Matthias; Biggs, William H; Viars, Carrie S; Czekay, Suzanne; Arden, Karen C; Heath, Joan K.

J Biol Chem ; 277(37): 34531-9, 2002 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-12114523

19.

Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling.

Arden, Karen C; Biggs, William H.

Arch Biochem Biophys ; 403(2): 292-8, 2002 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-12139979

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Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass.

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.

The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer.

Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling.

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.

Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor.

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.

FoxOs in tumor suppression and stem cell maintenance.

Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube.

FoxO: linking new signaling pathways.

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.

Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.

Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling.